ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: proprotein convertase subtilisin/kexin type 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140479 PCSK6 9606 - 15:101297142-101525202 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000331826 PCSK6-201 101364908-101489984 protein_coding
  ENST00000398185 PCSK6-008 101303929-101443663 protein_coding
  ENST00000557794 PCSK6-009 101304746-101525202 processed_transcript
  ENST00000558154 PCSK6-007 101365785-101382206 retained_intron
  ENST00000558433 PCSK6-015 101305128-101316389 processed_transcript
  ENST00000558864 PCSK6-011 101297142-101313402 protein_coding
  ENST00000558951 PCSK6-012 101300613-101366262 protein_coding
  ENST00000559417 PCSK6-010 101384322-101489435 protein_coding
  ENST00000559430 PCSK6-013 101305231-101308940 processed_transcript
  ENST00000559499 PCSK6-006 101303931-101309112 retained_intron
  ENST00000559605 PCSK6-017 101324939-101370468 protein_coding
  ENST00000560785 PCSK6-014 101307291-101313847 retained_intron
  ENST00000560902 PCSK6-018 101326381-101382124 processed_transcript
  ENST00000611716 PCSK6-001 101303928-101489839 protein_coding
  ENST00000611967 PCSK6-002 101346373-101489697 protein_coding
  ENST00000615296 PCSK6-019 101346742-101489697 protein_coding
  ENST00000618548 PCSK6-005 101303934-101489744 protein_coding
  ENST00000619160 PCSK6-004 101313017-101489744 protein_coding
  ENST00000621185 PCSK6-016 101364874-101370488 protein_coding
  ENST00000622483 PCSK6-003 101313017-101489744 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000331826ENST00000398185ENST00000557794ENST00000558154ENST00000558433ENST00000558864ENST00000559417ENST00000559499ENST00000611716ENST00000615296ENST00000618548ENST00000619160ENST00000622483
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000331826 N/A N/A N/A N/A 0.035±0.00
ENST00000398185 0.121±0.00 0.273±0.15 N/A 1.603±0.00 0.121±0.06
ENST00000557794 N/A N/A N/A N/A 0.113±0.02
ENST00000558154 N/A N/A N/A N/A 0.114±0.04
ENST00000558433 1.507±0.00 N/A N/A N/A N/A
ENST00000558864 0.230±0.00 0.212±0.11 N/A N/A 0.054±0.03
ENST00000559417 N/A 0.524±0.00 N/A N/A 0.290±0.13
ENST00000559499 N/A N/A N/A N/A 0.072±0.02
ENST00000611716 N/A N/A N/A N/A 0.102±0.00
ENST00000615296 N/A N/A N/A N/A 0.049±0.03
ENST00000618548 N/A 0.157±0.05 0.736±0.00 0.756±0.00 0.088±0.05
ENST00000619160 N/A N/A N/A N/A 0.187±0.00
ENST00000622483 N/A N/A N/A N/A 0.278±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IDA endopeptidase activity
GO:0004252 IEA serine-type endopeptidase activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0005783 IEA endoplasmic reticulum
GO:0005796 TAS Golgi lumen
GO:0006508 IEA proteolysis
GO:0007354 IEA zygotic determination of anterior/posterior axis, embryo
GO:0007368 IEA determination of left/right symmetry
GO:0008201 IDA heparin binding
GO:0008233 IEA peptidase activity
GO:0009100 IDA glycoprotein metabolic process
GO:0009986 IDA cell surface
GO:0016020 IEA membrane
GO:0016485 IDA protein processing
GO:0016486 IDA peptide hormone processing
GO:0030510 TAS regulation of BMP signaling pathway
GO:0031012 IDA extracellular matrix
GO:0032455 TAS nerve growth factor processing
GO:0032902 IDA nerve growth factor production
GO:0032940 IDA secretion by cell
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048406 IDA nerve growth factor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000030513 Pcsk6 protein_coding Mus_musculus

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