ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: EPH receptor A2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142627 EPHA2 9606 - 1:16124337-16156087 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000358432 EPHA2-001 16124337-16156087 protein_coding
  ENST00000461614 EPHA2-002 16148378-16156052 processed_transcript
  ENST00000462805 EPHA2-004 16133013-16133562 processed_transcript
  ENST00000480202 EPHA2-003 16134560-16146450 processed_transcript
  ENST00000611929 EPHA2-201 16124338-16156087 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHMVEC-DHUVECENST00000358432ENST00000461614ENST00000611929
Transcript ID HAoEC HHSEC HMVEC-D HUVEC
ENST00000358432 31.941±7.10 10.967±0.00 36.700±0.00 37.079±23.88
ENST00000461614 N/A N/A N/A 9.218±6.54
ENST00000611929 8.732±1.04 N/A 7.948±0.00 1.459±0.79

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007QM CIL_0007QM_0001 VISTA
CIL_00022W CIL_00022W_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IEA skeletal system development
GO:0001525 IEA angiogenesis
GO:0001568 IEA blood vessel development
GO:0001570 IEA vasculogenesis
GO:0001649 ISS osteoblast differentiation
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IDA transmembrane receptor protein tyrosine kinase activity
GO:0005003 IEA ephrin receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005886 IDA plasma membrane
GO:0005887 IDA:IEA integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006468 IEA protein phosphorylation
GO:0007155 IEA cell adhesion
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 TAS multicellular organismal development
GO:0008630 IDA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 IDA cell surface
GO:0010591 IMP regulation of lamellipodium assembly
GO:0014028 IEA notochord formation
GO:0016032 IEA viral process
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021915 IEA neural tube development
GO:0030182 IEA neuron differentiation
GO:0030216 IMP keratinocyte differentiation
GO:0030316 ISS osteoclast differentiation
GO:0031256 IDA leading edge membrane
GO:0032863 IMP activation of Rac GTPase activity
GO:0033598 ISS mammary gland epithelial cell proliferation
GO:0033628 IDA regulation of cell adhesion mediated by integrin
GO:0036342 IEA post-anal tail morphogenesis
GO:0042995 IEA cell projection
GO:0043491 IDA protein kinase B signaling
GO:0043535 ISS regulation of blood vessel endothelial cell migration
GO:0045765 ISS regulation of angiogenesis
GO:0046849 ISS bone remodeling
GO:0048013 IDA:IEA ephrin receptor signaling pathway
GO:0048320 IEA axial mesoderm formation
GO:0048570 IEA notochord morphogenesis
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0060035 IEA notochord cell development
GO:0060326 IMP cell chemotaxis
GO:0060444 ISS branching involved in mammary gland duct morphogenesis
GO:0070309 ISS lens fiber cell morphogenesis
GO:0070372 IMP regulation of ERK1 and ERK2 cascade
GO:0070848 IMP response to growth factor
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017354 epha2a protein_coding Danio_rerio
ENSDARG00000022727 EPHA2 (2 of 2) protein_coding Danio_rerio
ENSMUSG00000006445 Epha2 protein_coding Mus_musculus

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