ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006445 Epha2 10090 + 4:141301240-141329384 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000006614 Epha2-001 141301240-141329384 protein_coding
  ENSMUST00000131026 Epha2-002 141302407-141308734 processed_transcript
  ENSMUST00000145523 Epha2-003 141308894-141310958 processed_transcript
  ENSMUST00000149002 Epha2-004 141316913-141320901 processed_transcript

Mus musculus Ensembl GRCm38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000006614ENSMUST00000149002
Transcript ID C166 Tie2+ EC mES
ENSMUST00000006614 31.986±5.89 31.199±26.46 0.392±0.04
ENSMUST00000149002 N/A N/A 0.643±0.12

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007QM CIL_0007QM_0002 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IMP skeletal system development
GO:0001525 IEA angiogenesis
GO:0001568 IMP blood vessel development
GO:0001570 IMP vasculogenesis
GO:0001649 IMP osteoblast differentiation
GO:0004714 ISS transmembrane receptor protein tyrosine kinase activity
GO:0005003 IEA ephrin receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005886 IEA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0005925 ISS focal adhesion
GO:0007155 IEA cell adhesion
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 IEA cell surface
GO:0010591 ISS regulation of lamellipodium assembly
GO:0014028 IGI notochord formation
GO:0016477 ISS cell migration
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021915 IMP neural tube development
GO:0030182 IDA neuron differentiation
GO:0030216 IEA keratinocyte differentiation
GO:0030316 IDA osteoclast differentiation
GO:0031256 ISS leading edge membrane
GO:0032863 ISS activation of Rac GTPase activity
GO:0033598 IMP mammary gland epithelial cell proliferation
GO:0033628 ISS regulation of cell adhesion mediated by integrin
GO:0036342 IMP post-anal tail morphogenesis
GO:0042995 IEA cell projection
GO:0043491 ISS protein kinase B signaling
GO:0043535 IDA regulation of blood vessel endothelial cell migration
GO:0045765 IDA regulation of angiogenesis
GO:0046849 IMP bone remodeling
GO:0048013 IDA ephrin receptor signaling pathway
GO:0048320 IMP axial mesoderm formation
GO:0048570 IMP notochord morphogenesis
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0060035 IMP notochord cell development
GO:0060326 ISS cell chemotaxis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0070309 IDA lens fiber cell morphogenesis
GO:0070372 IEA regulation of ERK1 and ERK2 cascade
GO:0070848 ISS response to growth factor
GO:0090004 ISS positive regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017354 epha2a protein_coding Danio_rerio
ENSDARG00000022727 EPHA2 (2 of 2) protein_coding Danio_rerio
ENSG00000142627 EPHA2 EPH receptor A2 protein_coding Homo_sapiens

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