ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ADAM metallopeptidase domain 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151651 ADAM8 9606 - 10:133262403-133276868 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000415217 ADAM8-009 133262420-133276850 protein_coding
  ENST00000445355 ADAM8-001 133262403-133276868 protein_coding
  ENST00000463298 ADAM8-003 133272738-133276856 retained_intron
  ENST00000468964 ADAM8-002 133270453-133271425 retained_intron
  ENST00000485491 ADAM8-005 133262968-133276868 protein_coding
  ENST00000486609 ADAM8-004 133273286-133276857 protein_coding
  ENST00000537099 ADAM8-008 133271814-133275994 retained_intron
  ENST00000559018 ADAM8-011 133263003-133263865 retained_intron
  ENST00000559180 ADAM8-006 133273305-133276868 processed_transcript
  ENST00000560135 ADAM8-007 133272415-133276863 nonsense_mediated_decay
  ENST00000561175 ADAM8-010 133271717-133272576 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000415217ENST00000445355ENST00000463298ENST00000468964ENST00000485491ENST00000537099ENST00000559018ENST00000559180ENST00000560135ENST00000561175
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000415217 N/A 0.207±0.34 0.958±0.00 0.079±0.07
ENST00000445355 N/A 0.457±0.57 N/A 0.100±0.08
ENST00000463298 N/A 0.006±0.00 N/A N/A
ENST00000468964 N/A N/A N/A 0.176±0.06
ENST00000485491 N/A 0.011±0.00 N/A 0.137±0.15
ENST00000537099 N/A N/A N/A 0.040±0.03
ENST00000559018 N/A N/A N/A 0.108±0.00
ENST00000559180 N/A 0.461±0.40 N/A 0.116±0.00
ENST00000560135 N/A 0.335±0.00 N/A 0.066±0.03
ENST00000561175 1.706±0.00 0.635±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000479 CIL_000479_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 ISS cell morphogenesis
GO:0001525 ISS angiogenesis
GO:0002102 IDA podosome
GO:0002523 ISS leukocyte migration involved in inflammatory response
GO:0002675 ISS positive regulation of acute inflammatory response
GO:0002693 IEA positive regulation of cellular extravasation
GO:0004222 IEA metalloendopeptidase activity
GO:0005509 ISS calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA proteolysis
GO:0006954 IDA inflammatory response
GO:0008237 IDA metallopeptidase activity
GO:0008270 TAS:IEA zinc ion binding
GO:0009986 IDA cell surface
GO:0010954 NAS positive regulation of protein processing
GO:0016337 IEA single organismal cell-cell adhesion
GO:0022407 IDA regulation of cell-cell adhesion
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0032010 IDA phagolysosome
GO:0032127 IDA dense core granule membrane
GO:0033089 ISS positive regulation of T cell differentiation in thymus
GO:0035419 ISS activation of MAPK activity involved in innate immune response
GO:0042581 IDA specific granule
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043621 TAS protein self-association
GO:0045780 ISS positive regulation of bone resorption
GO:0045785 ISS positive regulation of cell adhesion
GO:0048247 ISS lymphocyte chemotaxis
GO:0050714 IC positive regulation of protein secretion
GO:0050729 IEA positive regulation of inflammatory response
GO:0050839 IPI cell adhesion molecule binding
GO:0051044 IDA positive regulation of membrane protein ectodomain proteolysis
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051897 ISS positive regulation of protein kinase B signaling
GO:0070245 ISS positive regulation of thymocyte apoptotic process
GO:0070820 IDA tertiary granule
GO:0071065 IDA alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133 ISS alpha9-beta1 integrin-ADAM8 complex
GO:0071456 IDA cellular response to hypoxia
GO:2000309 ISS positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391 IDA positive regulation of neutrophil extravasation
GO:2000406 IEA positive regulation of T cell migration
GO:2000415 ISS positive regulation of fibronectin-dependent thymocyte migration
GO:2000418 ISS positive regulation of eosinophil migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001452 adam8a protein_coding Danio_rerio
ENSDARG00000057644 adam8b protein_coding Danio_rerio
ENSMUSG00000025473 Adam8 protein_coding Mus_musculus

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