ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025473 Adam8 10090 - 7:139978932-139992562 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026546 Adam8-002 139978932-139992548 protein_coding
  ENSMUST00000106069 Adam8-001 139978932-139992562 protein_coding
  ENSMUST00000128332 Adam8-004 139978932-139992562 retained_intron
  ENSMUST00000132903 Adam8-007 139979394-139980368 processed_transcript
  ENSMUST00000148670 Adam8-005 139983854-139992562 protein_coding
  ENSMUST00000149915 Adam8-006 139987654-139988430 processed_transcript
  ENSMUST00000156647 Adam8-003 139978932-139988434 retained_intron
  ENSMUST00000173209 Adam8-008 139989419-139992508 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000026546ENSMUST00000106069ENSMUST00000128332ENSMUST00000156647
Transcript ID C166 Tie2+ EC mES
ENSMUST00000026546 0.162±0.02 0.163±0.00 0.115±0.00
ENSMUST00000106069 N/A 0.143±0.00 N/A
ENSMUST00000128332 N/A 0.027±0.00 0.153±0.00
ENSMUST00000156647 0.122±0.00 0.072±0.00 0.099±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000479 CIL_000479_0003 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IMP cell morphogenesis
GO:0001525 IDA angiogenesis
GO:0002102 ISS podosome
GO:0002523 IMP leukocyte migration involved in inflammatory response
GO:0002675 IMP positive regulation of acute inflammatory response
GO:0002693 IMP positive regulation of cellular extravasation
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 TAS integrin binding
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006508 IEA proteolysis
GO:0006954 IEA inflammatory response
GO:0007160 TAS cell-matrix adhesion
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0009986 IEA cell surface
GO:0016337 IDA single organismal cell-cell adhesion
GO:0022407 ISS regulation of cell-cell adhesion
GO:0032010 ISS phagolysosome
GO:0032127 ISS dense core granule membrane
GO:0033089 IDA positive regulation of T cell differentiation in thymus
GO:0035419 IDA activation of MAPK activity involved in innate immune response
GO:0042581 ISS specific granule
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043534 NAS blood vessel endothelial cell migration
GO:0045670 NAS regulation of osteoclast differentiation
GO:0045780 IDA positive regulation of bone resorption
GO:0045785 IDA positive regulation of cell adhesion
GO:0048247 IDA lymphocyte chemotaxis
GO:0048729 TAS tissue morphogenesis
GO:0050729 IDA positive regulation of inflammatory response
GO:0050839 IPI cell adhesion molecule binding
GO:0051044 IDA positive regulation of membrane protein ectodomain proteolysis
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0061025 TAS membrane fusion
GO:0070245 IMP positive regulation of thymocyte apoptotic process
GO:0070820 ISS tertiary granule
GO:0071065 ISS alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133 IDA alpha9-beta1 integrin-ADAM8 complex
GO:0071456 ISS cellular response to hypoxia
GO:0072675 TAS osteoclast fusion
GO:2000309 IMP positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391 IEA positive regulation of neutrophil extravasation
GO:2000399 NAS negative regulation of thymocyte aggregation
GO:2000406 IMP positive regulation of T cell migration
GO:2000415 IMP positive regulation of fibronectin-dependent thymocyte migration
GO:2000418 IMP positive regulation of eosinophil migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001452 adam8a protein_coding Danio_rerio
ENSDARG00000057644 adam8b protein_coding Danio_rerio
ENSG00000151651 ADAM8 ADAM metallopeptidase domain 8 protein_coding Homo_sapiens

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