ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157193 LRP8 9606 - 1:53245539-53328070 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306052 LRP8-001 53245539-53328014 protein_coding
  ENST00000347547 LRP8-011 53247018-53327912 protein_coding
  ENST00000354412 LRP8-003 53246568-53327912 protein_coding
  ENST00000371454 LRP8-002 53246553-53328054 protein_coding
  ENST00000459674 LRP8-006 53250765-53268598 retained_intron
  ENST00000460214 LRP8-007 53257243-53262497 processed_transcript
  ENST00000465675 LRP8-004 53246568-53327399 protein_coding
  ENST00000475501 LRP8-009 53264169-53275663 protein_coding
  ENST00000480045 LRP8-005 53246958-53328070 nonsense_mediated_decay
  ENST00000481431 LRP8-008 53260464-53266589 nonsense_mediated_decay
  ENST00000496580 LRP8-010 53289332-53327817 retained_intron
  ENST00000529670 LRP8-012 53245749-53257323 nonsense_mediated_decay
  ENST00000613948 LRP8-201 53246568-53327912 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000306052ENST00000347547ENST00000354412ENST00000371454ENST00000459674ENST00000460214ENST00000465675ENST00000475501ENST00000529670ENST00000613948
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000306052 N/A 5.205±2.63 0.134±0.00 1.779±0.00 2.489±1.66
ENST00000347547 N/A 2.032±0.36 N/A N/A 3.404±1.71
ENST00000354412 N/A 7.271±0.00 N/A N/A 1.533±0.63
ENST00000371454 N/A 1.163±0.00 N/A N/A 1.085±1.22
ENST00000459674 N/A N/A N/A N/A 1.650±0.00
ENST00000460214 N/A 6.351±0.55 N/A N/A N/A
ENST00000465675 N/A 1.708±0.00 N/A N/A 2.598±1.28
ENST00000475501 N/A 7.131±0.00 N/A N/A 6.628±3.86
ENST00000529670 3.492±0.00 13.581±4.37 0.426±0.00 N/A 7.567±0.00
ENST00000613948 N/A N/A N/A N/A 2.787±0.58

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001523 TAS retinoid metabolic process
GO:0004888 TAS transmembrane signaling receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 IEA extracellular region
GO:0005875 IEA microtubule associated complex
GO:0005886 TAS plasma membrane
GO:0005901 IDA caveola
GO:0006508 NAS proteolysis
GO:0006629 NAS lipid metabolic process
GO:0006897 IDA endocytosis
GO:0006898 IDA receptor-mediated endocytosis
GO:0007165 TAS signal transduction
GO:0007596 TAS blood coagulation
GO:0007603 TAS phototransduction, visible light
GO:0008035 IEA high-density lipoprotein particle binding
GO:0014069 IEA postsynaptic density
GO:0016020 IDA membrane
GO:0016021 IC integral component of membrane
GO:0019221 NAS cytokine-mediated signaling pathway
GO:0019894 IEA kinesin binding
GO:0021541 ISS ammon gyrus development
GO:0021766 IEA hippocampus development
GO:0021819 IEA layer formation in cerebral cortex
GO:0021987 IEA cerebral cortex development
GO:0030229 IDA very-low-density lipoprotein particle receptor activity
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032793 ISS positive regulation of CREB transcription factor activity
GO:0034185 IC apolipoprotein binding
GO:0038025 ISS reelin receptor activity
GO:0038026 ISS reelin-mediated signaling pathway
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043235 IDA receptor complex
GO:0045860 IEA positive regulation of protein kinase activity
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 ISS regulation of synaptic transmission
GO:0061003 ISS positive regulation of dendritic spine morphogenesis
GO:0061098 ISS positive regulation of protein tyrosine kinase activity
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071397 IEA cellular response to cholesterol
GO:1900006 ISS positive regulation of dendrite development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070074 lrp8 protein_coding Danio_rerio
ENSMUSG00000028613 Lrp8 protein_coding Mus_musculus

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