ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028613 Lrp8 10090 + 4:107802261-107876840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000030356 Lrp8-006 107802314-107873899 protein_coding
  ENSMUST00000106731 Lrp8-003 107830985-107876840 protein_coding
  ENSMUST00000106732 Lrp8-002 107802413-107872346 protein_coding
  ENSMUST00000106733 Lrp8-007 107802277-107872816 protein_coding
  ENSMUST00000123140 Lrp8-004 107823161-107872816 processed_transcript
  ENSMUST00000126573 Lrp8-008 107802413-107872816 protein_coding
  ENSMUST00000135022 Lrp8-012 107850128-107856864 processed_transcript
  ENSMUST00000135591 Lrp8-011 107846201-107848295 retained_intron
  ENSMUST00000143601 Lrp8-001 107802261-107874167 nonsense_mediated_decay
  ENSMUST00000145832 Lrp8-005 107830965-107837221 retained_intron
  ENSMUST00000146552 Lrp8-009 107803251-107872816 processed_transcript
  ENSMUST00000147319 Lrp8-010 107802842-107851362 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000030356ENSMUST00000106731ENSMUST00000106732ENSMUST00000106733ENSMUST00000123140ENSMUST00000146552
Transcript ID C166 Tie2+ EC mES
ENSMUST00000030356 0.197±0.13 11.852±8.26 1.063±0.17
ENSMUST00000106731 0.109±0.04 15.865±15.59 0.814±0.31
ENSMUST00000106732 0.287±0.13 N/A N/A
ENSMUST00000106733 0.108±0.00 N/A N/A
ENSMUST00000123140 0.139±0.00 N/A N/A
ENSMUST00000146552 0.399±0.22 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00083F CIL_00083F_0002 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001948 IPI glycoprotein binding
GO:0005041 TAS low-density lipoprotein receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005875 IEA microtubule associated complex
GO:0005886 TAS plasma membrane
GO:0005901 IEA caveola
GO:0006897 IEA endocytosis
GO:0006898 TAS receptor-mediated endocytosis
GO:0008035 IEA high-density lipoprotein particle binding
GO:0014069 IEA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019894 IEA kinesin binding
GO:0021517 IEP ventral spinal cord development
GO:0021541 IMP ammon gyrus development
GO:0021766 IGI hippocampus development
GO:0021819 IGI layer formation in cerebral cortex
GO:0021987 IEA cerebral cortex development
GO:0030229 IEA very-low-density lipoprotein particle receptor activity
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032793 IMP positive regulation of CREB transcription factor activity
GO:0034185 IDA apolipoprotein binding
GO:0038025 IMP reelin receptor activity
GO:0038026 IMP reelin-mediated signaling pathway
GO:0042493 IEA response to drug
GO:0043025 IEA neuronal cell body
GO:0043235 ISO receptor complex
GO:0045860 IGI positive regulation of protein kinase activity
GO:0048306 IPI calcium-dependent protein binding
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 IMP regulation of synaptic transmission
GO:0061003 IMP positive regulation of dendritic spine morphogenesis
GO:0061098 IMP positive regulation of protein tyrosine kinase activity
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071397 IEA cellular response to cholesterol
GO:1900006 IGI positive regulation of dendrite development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070074 lrp8 protein_coding Danio_rerio
ENSG00000157193 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor protein_coding Homo_sapiens

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