ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SHC (Src homology 2 domain containing) transforming protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160691 SHC1 9606 - 1:154962298-154974395 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366442 SHC1-009 154968502-154974395 protein_coding
  ENST00000368445 SHC1-001 154962298-154970741 protein_coding
  ENST00000368449 SHC1-003 154962298-154970747 protein_coding
  ENST00000368450 SHC1-007 154962298-154974376 protein_coding
  ENST00000368453 SHC1-006 154962298-154974376 protein_coding
  ENST00000412170 SHC1-008 154967670-154974336 protein_coding
  ENST00000414115 SHC1-004 154965992-154968893 protein_coding
  ENST00000444179 SHC1-005 154966425-154968874 protein_coding
  ENST00000444664 SHC1-010 154963677-154966490 protein_coding
  ENST00000448116 SHC1-002 154962298-154970747 protein_coding
  ENST00000490667 SHC1-011 154963329-154965762 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000368445ENST00000368449ENST00000368450ENST00000368453ENST00000448116
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000368445 N/A 39.774±19.72 N/A 60.410±0.00 61.153±35.10
ENST00000368449 52.072±31.51 43.569±9.13 63.219±0.00 N/A 46.244±22.50
ENST00000368450 N/A 10.468±1.36 N/A N/A 26.833±16.87
ENST00000368453 42.563±0.00 40.252±13.31 59.655±0.00 44.936±0.00 42.662±26.92
ENST00000448116 18.455±2.19 64.359±27.41 31.083±0.00 78.781±0.00 76.495±54.32

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IDA MAPK cascade
GO:0000187 IDA activation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0004713 TAS protein tyrosine kinase activity
GO:0005068 TAS transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005154 ISS epidermal growth factor receptor binding
GO:0005158 IPI insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005168 IPI neurotrophin TRKA receptor binding
GO:0005515 IEA protein binding
GO:0005543 TAS phospholipid binding
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007176 TAS regulation of epidermal growth factor-activated receptor activity
GO:0007265 TAS Ras protein signal transduction
GO:0007507 IEA heart development
GO:0007596 TAS blood coagulation
GO:0008284 NAS positive regulation of cell proliferation
GO:0008286 ISS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016337 IEA single organismal cell-cell adhesion
GO:0018108 TAS peptidyl-tyrosine phosphorylation
GO:0030168 TAS platelet activation
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0030971 IEA receptor tyrosine kinase binding
GO:0031532 IEA actin cytoskeleton reorganization
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040008 IEA regulation of growth
GO:0042127 IEA regulation of cell proliferation
GO:0044267 TAS cellular protein metabolic process
GO:0045087 TAS innate immune response
GO:0045740 ISS positive regulation of DNA replication
GO:0046875 IPI ephrin receptor binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0070435 ISS Shc-EGFR complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075437 shc1 protein_coding Danio_rerio
ENSMUSG00000042626 Shc1 protein_coding Mus_musculus

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