ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: absent in melanoma 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163568 AIM2 9606 - 1:159062484-159147096 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368129 AIM2-004 159063579-159140508 protein_coding
  ENST00000368130 AIM2-001 159062484-159076901 protein_coding
  ENST00000411768 AIM2-002 159066316-159147096 processed_transcript
  ENST00000481829 AIM2-003 159063532-159073265 processed_transcript
  ENST00000612470 AIM2-201 159062485-159076855 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHUVECENST00000368129ENST00000368130ENST00000411768ENST00000481829ENST00000612470
Transcript ID HAoEC HHSEC HUVEC
ENST00000368129 N/A N/A 0.090±0.02
ENST00000368130 N/A N/A 0.031±0.00
ENST00000411768 0.096±0.00 0.063±0.00 0.073±0.03
ENST00000481829 N/A N/A 0.080±0.00
ENST00000612470 0.020±0.00 0.060±0.00 0.042±0.02

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002218 IDA activation of innate immune response
GO:0002230 ISS positive regulation of defense response to virus by host
GO:0003690 IDA double-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0006955 TAS immune response
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0032461 IDA positive regulation of protein oligomerization
GO:0032731 IDA positive regulation of interleukin-1 beta production
GO:0033209 IDA tumor necrosis factor-mediated signaling pathway
GO:0035458 IEA cellular response to interferon-beta
GO:0035690 IDA cellular response to drug
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042802 IPI identical protein binding
GO:0045087 TAS innate immune response
GO:0050702 IMP interleukin-1 beta secretion
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070269 IDA pyroptosis
GO:0097169 IDA AIM2 inflammasome complex
GO:2001056 IDA positive regulation of cysteine-type endopeptidase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037860 Aim2 protein_coding Mus_musculus

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