ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: hypoxia inducible factor 1, alpha subunit inhibitor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166135 HIF1AN 9606 + 10:100529072-100559998 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299163 HIF1AN-002 100535859-100559998 protein_coding
  ENST00000478787 HIF1AN-003 100536470-100545497 retained_intron
  ENST00000526476 HIF1AN-005 100535915-100545968 nonsense_mediated_decay
  ENST00000528044 HIF1AN-006 100536198-100540728 processed_transcript
  ENST00000533589 HIF1AN-004 100529072-100546581 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000299163
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000299163 3.462±0.00 6.582±3.32 4.478±0.00 4.339±1.85

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007QB CIL_0007QB_0001 VISTA
CIL_00082U CIL_00082U_0001 VISTA
CIL_00082V CIL_00082V_0001 VISTA
CIL_00093R CIL_00093R_0001 VISTA
CIL_00093O CIL_00093O_0001 VISTA
CIL_0008BC CIL_0008BC_0001 VISTA
CIL_0001CC CIL_0001CC_0002 CGP
CIL_0008BD CIL_0008BD_0001 VISTA
CIL_0007U1 CIL_0007U1_0001 VISTA
CIL_0005DQ CIL_0005DQ_0001 CGP
CIL_0005DR CIL_0005DR_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005112 IPI Notch binding
GO:0005506 IDA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0008270 IDA zinc ion binding
GO:0016706 EXP oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826 NAS oxygen sensor activity
GO:0031406 IDA carboxylic acid binding
GO:0036138 IDA peptidyl-histidine hydroxylation
GO:0036139 IDA peptidyl-histidine dioxygenase activity
GO:0036140 IDA peptidyl-asparagine 3-dioxygenase activity
GO:0042264 IDA peptidyl-aspartic acid hydroxylation
GO:0042265 IDA peptidyl-asparagine hydroxylation
GO:0042803 IDA protein homodimerization activity
GO:0045663 IDA positive regulation of myoblast differentiation
GO:0045746 IDA negative regulation of Notch signaling pathway
GO:0048037 IDA cofactor binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051059 IPI NF-kappaB binding
GO:0055114 IDA oxidation-reduction process
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428 IDA negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia
GO:0071532 IPI ankyrin repeat binding
GO:2001214 NAS positive regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031915 hif1an protein_coding Danio_rerio
ENSMUSG00000036450 Hif1an protein_coding Mus_musculus

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