ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: inositol polyphosphate-5-phosphatase, 145kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168918 INPP5D 9606 + 2:233059967-233207903 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359570 INPP5D-001 233059967-233207903 protein_coding
  ENST00000415617 INPP5D-015 233161724-233207903 protein_coding
  ENST00000417661 INPP5D-013 233195437-233206952 protein_coding
  ENST00000445964 INPP5D-006 233060398-233207902 protein_coding
  ENST00000451407 INPP5D-016 233060366-233141608 retained_intron
  ENST00000465281 INPP5D-010 233170374-233184483 retained_intron
  ENST00000467393 INPP5D-003 233076262-233125805 processed_transcript
  ENST00000472517 INPP5D-007 233164301-233170576 processed_transcript
  ENST00000474278 INPP5D-004 233120602-233130648 processed_transcript
  ENST00000480983 INPP5D-009 233170021-233171249 retained_intron
  ENST00000491070 INPP5D-014 233204642-233205652 nonsense_mediated_decay
  ENST00000493078 INPP5D-012 233161789-233169329 retained_intron
  ENST00000493632 INPP5D-008 233169560-233182482 retained_intron
  ENST00000496402 INPP5D-011 233122216-233130859 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000359570ENST00000415617ENST00000445964ENST00000451407ENST00000493632
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000359570 0.524±0.00 1.712±1.04 1.292±0.00 3.103±2.16
ENST00000415617 5.461±0.00 2.653±1.39 2.893±0.00 1.708±0.78
ENST00000445964 0.808±0.00 4.958±4.09 6.545±0.00 6.456±4.90
ENST00000451407 N/A N/A N/A 1.331±0.63
ENST00000493632 N/A N/A N/A 3.546±1.50

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003HY CIL_0003HY_0001 CGP
CIL_0003HZ CIL_0003HZ_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004445 IEA inositol-polyphosphate 5-phosphatase activity
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0006796 TAS phosphate-containing compound metabolic process
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007596 TAS blood coagulation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008340 IEA determination of adult lifespan
GO:0009968 IEA negative regulation of signal transduction
GO:0016020 IEA membrane
GO:0016064 IEA immunoglobulin mediated immune response
GO:0016311 IEA dephosphorylation
GO:0017124 IEA SH3 domain binding
GO:0030853 IEA negative regulation of granulocyte differentiation
GO:0030889 IEA negative regulation of B cell proliferation
GO:0034594 IEA phosphatidylinositol trisphosphate phosphatase activity
GO:0035556 IEA intracellular signal transduction
GO:0043065 IEA positive regulation of apoptotic process
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045409 IEA negative regulation of interleukin-6 biosynthetic process
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045621 IEA positive regulation of lymphocyte differentiation
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045656 IEA negative regulation of monocyte differentiation
GO:0045659 IEA negative regulation of neutrophil differentiation
GO:0045671 IEA negative regulation of osteoclast differentiation
GO:0045779 IEA negative regulation of bone resorption
GO:0046856 IEA phosphatidylinositol dephosphorylation
GO:0050777 IEA negative regulation of immune response
GO:0050852 TAS T cell receptor signaling pathway
GO:0050869 IEA negative regulation of B cell activation
GO:0050900 TAS leukocyte migration
GO:0051425 IEA PTB domain binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074283 inpp5d protein_coding Danio_rerio
ENSMUSG00000026288 Inpp5d protein_coding Mus_musculus

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