ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: insulin receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000171105 INSR 9606 - 19:7112255-7294034 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302850 INSR-001 7116627-7294034 protein_coding
  ENST00000341500 INSR-002 7112255-7293931 protein_coding
  ENST00000593970 INSR-007 7122570-7125386 retained_intron
  ENST00000597211 INSR-006 7141510-7143040 retained_intron
  ENST00000598216 INSR-003 7151971-7293866 retained_intron
  ENST00000600492 INSR-004 7159423-7167978 protein_coding
  ENST00000601099 INSR-005 7120620-7123158 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000302850ENST00000341500ENST00000598216
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000302850 N/A 0.701±0.36 0.518±0.00 0.751±0.24
ENST00000341500 0.717±0.00 1.629±0.57 0.406±0.00 1.363±0.61
ENST00000598216 N/A N/A N/A 0.538±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000434 CIL_000434_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0003007 IMP heart morphogenesis
GO:0004672 IEA protein kinase activity
GO:0004713 IMP:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004716 IDA receptor signaling protein tyrosine kinase activity
GO:0005009 IDA insulin-activated receptor activity
GO:0005159 IDA insulin-like growth factor receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005525 IDA GTP binding
GO:0005886 IC plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005899 IMP insulin receptor complex
GO:0005901 IDA caveola
GO:0005975 IEA carbohydrate metabolic process
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0008284 IC positive regulation of cell proliferation
GO:0008286 IDA insulin receptor signaling pathway
GO:0008544 IEA epidermis development
GO:0009887 IEA organ morphogenesis
GO:0010008 TAS endosome membrane
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019087 IMP transformation of host cell by virus
GO:0023014 IDA signal transduction by phosphorylation
GO:0030238 IEA male sex determination
GO:0030335 IMP positive regulation of cell migration
GO:0031017 IEA exocrine pancreas development
GO:0031994 IPI insulin-like growth factor I binding
GO:0031995 IPI insulin-like growth factor II binding
GO:0032147 IMP activation of protein kinase activity
GO:0032148 IDA activation of protein kinase B activity
GO:0032869 IDA cellular response to insulin stimulus
GO:0038083 IEA peptidyl-tyrosine autophosphorylation
GO:0042593 IMP glucose homeostasis
GO:0043235 IDA receptor complex
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043548 IPI:IEA phosphatidylinositol 3-kinase binding
GO:0043559 IDA insulin binding
GO:0043560 IPI:IEA insulin receptor substrate binding
GO:0045429 IMP positive regulation of nitric oxide biosynthetic process
GO:0045725 IDA positive regulation of glycogen biosynthetic process
GO:0045740 IMP positive regulation of DNA replication
GO:0045821 IMP positive regulation of glycolytic process
GO:0045840 IMP positive regulation of mitosis
GO:0045995 IMP regulation of embryonic development
GO:0046326 NAS positive regulation of glucose import
GO:0046777 IDA:IEA protein autophosphorylation
GO:0048639 IMP positive regulation of developmental growth
GO:0051290 IDA protein heterotetramerization
GO:0051425 IPI PTB domain binding
GO:0051897 IMP positive regulation of protein kinase B signaling
GO:0060267 IDA positive regulation of respiratory burst
GO:0070062 IDA extracellular vesicular exosome
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011948 insra protein_coding Danio_rerio
ENSDARG00000071524 insrb protein_coding Danio_rerio
ENSMUSG00000005534 Insr protein_coding Mus_musculus

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