ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: mitogen-activated protein kinase kinase kinase 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173327 MAP3K11 9606 - 11:65597755-65615382 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309100 MAP3K11-001 65597755-65614242 protein_coding
  ENST00000524848 MAP3K11-005 65597758-65608422 nonsense_mediated_decay
  ENST00000524856 MAP3K11-002 65606435-65615382 retained_intron
  ENST00000526293 MAP3K11-012 65607802-65614249 protein_coding
  ENST00000526647 MAP3K11-007 65605722-65606396 retained_intron
  ENST00000527304 MAP3K11-003 65608632-65614236 retained_intron
  ENST00000529839 MAP3K11-013 65607930-65614248 protein_coding
  ENST00000530153 MAP3K11-004 65597756-65611301 protein_coding
  ENST00000530949 MAP3K11-011 65607706-65608448 retained_intron
  ENST00000532507 MAP3K11-006 65597756-65607026 protein_coding
  ENST00000533032 MAP3K11-009 65607165-65607870 retained_intron
  ENST00000534110 MAP3K11-010 65608024-65608805 retained_intron
  ENST00000534432 MAP3K11-008 65599451-65606758 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000309100ENST00000524848ENST00000524856ENST00000527304ENST00000529839ENST00000532507
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000309100 26.111±5.90 50.419±17.50 31.106±0.00 55.785±0.00 61.881±71.03
ENST00000524848 29.984±2.74 N/A 50.231±0.00 N/A N/A
ENST00000524856 N/A N/A N/A N/A 0.229±0.00
ENST00000527304 N/A 2.180±0.18 N/A N/A 1.724±0.96
ENST00000529839 N/A N/A N/A N/A 101.332±15.34
ENST00000532507 124.928±40.20 N/A 93.185±0.00 N/A 20.365±2.69

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008W1 CIL_0008W1_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004706 ISS JUN kinase kinase kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005813 IDA centrosome
GO:0005874 IDA microtubule
GO:0006468 IDA:IEA protein phosphorylation
GO:0007017 IMP microtubule-based process
GO:0007254 TAS JNK cascade
GO:0007256 IEA activation of JNKK activity
GO:0007257 IMP activation of JUN kinase activity
GO:0008219 IEA cell death
GO:0008283 IMP cell proliferation
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 IDA protein autophosphorylation
GO:0048365 IEA Rac GTPase binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091521 MAP3K11 protein_coding Danio_rerio
ENSMUSG00000004054 Map3k11 protein_coding Mus_musculus

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