ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: mitogen-activated protein kinase kinase kinase 11
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000309100 MAP3K11-001 ENSG00000173327 9606 - 11:65597755-65614242 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000309100
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000309100 26.111±5.90 50.419±17.50 31.106±0.00 55.785±0.00 61.881±71.03

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004706 ISS JUN kinase kinase kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005813 IDA centrosome
GO:0005874 IDA microtubule
GO:0006468 IDA:IEA protein phosphorylation
GO:0007017 IMP microtubule-based process
GO:0007254 TAS JNK cascade
GO:0007256 IEA activation of JNKK activity
GO:0007257 IMP activation of JUN kinase activity
GO:0008219 IEA cell death
GO:0008283 IMP cell proliferation
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 IDA protein autophosphorylation
GO:0048365 IEA Rac GTPase binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000004156 Map3k11-201 protein_coding Mus_musculus 0 3591
ENSMUST00000108341 Map3k10-201 protein_coding Mus_musculus 0 442
ENSMUST00000036453 Map3k10-001 protein_coding Mus_musculus 0 442
ENSMUST00000138243 Map3k10-002 retained_intron Mus_musculus 0 287
ENSMUST00000133551 Map3k10-004 retained_intron Mus_musculus 3e-28 132

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