ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: methylenetetrahydrofolate reductase (NAD(P)H)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177000 MTHFR 9606 - 1:11785723-11806920 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000376486 MTHFR-003 11803028-11806920 protein_coding
  ENST00000376583 MTHFR-201 11785730-11803514 protein_coding
  ENST00000376585 MTHFR-007 11788294-11805413 protein_coding
  ENST00000376590 MTHFR-002 11786603-11806058 protein_coding
  ENST00000376592 MTHFR-001 11785723-11803245 protein_coding
  ENST00000413656 MTHFR-008 11803028-11805294 protein_coding
  ENST00000418034 MTHFR-004 11801205-11805936 protein_coding
  ENST00000423400 MTHFR-005 11803028-11805413 protein_coding
  ENST00000431243 MTHFR-006 11803028-11805413 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000376583ENST00000376585ENST00000376590ENST00000376592
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000376583 2.511±0.00 3.135±1.13 5.173±0.00 3.759±0.00 3.293±1.72
ENST00000376585 N/A N/A N/A N/A 1.153±0.76
ENST00000376590 N/A 1.698±0.63 N/A N/A 1.502±0.88
ENST00000376592 2.543±0.00 1.659±0.68 5.112±0.00 2.301±0.00 2.367±1.02

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00087H CIL_00087H_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0004489 IEA:TAS methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 TAS cytosol
GO:0006520 TAS cellular amino acid metabolic process
GO:0006555 IEA methionine metabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008015 TAS blood circulation
GO:0009086 IEA methionine biosynthetic process
GO:0033274 IEA response to vitamin B2
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043200 IEA response to amino acid
GO:0044281 TAS small molecule metabolic process
GO:0046500 IEA S-adenosylmethionine metabolic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0046655 TAS folic acid metabolic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0050667 IDA homocysteine metabolic process
GO:0051593 IEA response to folic acid
GO:0055114 IEA oxidation-reduction process
GO:0070555 IEA response to interleukin-1
GO:0072341 IDA modified amino acid binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053087 mthfr protein_coding Danio_rerio
ENSMUSG00000029009 Mthfr protein_coding Mus_musculus

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