ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: methylenetetrahydrofolate reductase (NAD(P)H)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000376592 MTHFR-001 ENSG00000177000 9606 - 1:11785723-11803245 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000376592
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000376592 2.543±0.00 1.659±0.68 5.112±0.00 2.301±0.00 2.367±1.02

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0004489 IEA:TAS methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 TAS cytosol
GO:0006520 TAS cellular amino acid metabolic process
GO:0006555 IEA methionine metabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008015 TAS blood circulation
GO:0009086 IEA methionine biosynthetic process
GO:0033274 IEA response to vitamin B2
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043200 IEA response to amino acid
GO:0044281 TAS small molecule metabolic process
GO:0046500 IEA S-adenosylmethionine metabolic process
GO:0046653 IEA tetrahydrofolate metabolic process
GO:0046655 TAS folic acid metabolic process
GO:0050660 IEA flavin adenine dinucleotide binding
GO:0050661 IEA NADP binding
GO:0050667 IDA homocysteine metabolic process
GO:0051593 IEA response to folic acid
GO:0055114 IEA oxidation-reduction process
GO:0070555 IEA response to interleukin-1
GO:0072341 IDA modified amino acid binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000152498 Mthfr-005 nonsense_mediated_decay Mus_musculus 0 2231
ENSMUST00000069604 Mthfr-001 protein_coding Mus_musculus 0 2231
ENSMUST00000097788 Mthfr-003 protein_coding Mus_musculus 0 2228
ENSMUST00000141283 Mthfr-002 protein_coding Mus_musculus 0 704
ENSMUST00000125978 Mthfr-007 retained_intron Mus_musculus 0 566
ENSMUST00000174153 Mthfr-ps1-001 processed_pseudogene Mus_musculus 0 542

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