ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: GEN1 Holliday junction 5' flap endonuclease
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000178295 GEN1 9606 + 2:17753858-17788941 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000317402 GEN1-001 17753858-17788941 protein_coding
  ENST00000381254 GEN1-201 17754147-17785365 protein_coding
  ENST00000524465 GEN1-002 17754147-17764927 protein_coding
  ENST00000528873 GEN1-005 17771076-17780770 processed_transcript
  ENST00000532257 GEN1-003 17754160-17761514 protein_coding
  ENST00000534451 GEN1-006 17772648-17774472 protein_coding
  ENST00000534669 GEN1-004 17761396-17765144 retained_intron
  ENST00000614478 GEN1-007 17753895-17755758 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000317402ENST00000381254ENST00000614478
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000317402 N/A N/A N/A N/A 0.041±0.00
ENST00000381254 0.807±0.01 1.826±1.75 1.129±0.00 2.504±0.00 2.655±2.39
ENST00000614478 N/A N/A N/A N/A 5.385±1.05

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000724 IMP double-strand break repair via homologous recombination
GO:0000737 IMP DNA catabolic process, endonucleolytic
GO:0003677 IEA DNA binding
GO:0003824 IEA catalytic activity
GO:0004518 IEA nuclease activity
GO:0005634 IEA nucleus
GO:0005813 IDA centrosome
GO:0006281 IEA DNA repair
GO:0008821 IMP crossover junction endodeoxyribonuclease activity
GO:0010824 IMP regulation of centrosome duplication
GO:0046872 IEA metal ion binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071139 IMP resolution of recombination intermediates
GO:0071140 IMP resolution of mitotic recombination intermediates
GO:0090267 IMP positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000051235 Gen1 protein_coding Mus_musculus

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