ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: endoplasmic reticulum to nucleus signaling 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000178607 ERN1 9606 - 17:64039142-64130819 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000433197 ERN1-001 64039142-64130125 protein_coding
  ENST00000577567 ERN1-005 64068237-64080474 processed_transcript
  ENST00000579249 ERN1-006 64067860-64072096 retained_intron
  ENST00000583028 ERN1-002 64097888-64130144 retained_intron
  ENST00000583077 ERN1-007 64053967-64054767 retained_intron
  ENST00000583896 ERN1-004 64060576-64066984 retained_intron
  ENST00000584041 ERN1-003 64075077-64130142 retained_intron
  ENST00000606895 ERN1-008 64128752-64130819 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000433197ENST00000584041ENST00000606895
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000433197 N/A 3.578±1.56 1.880±0.00 2.730±0.00 2.345±1.41
ENST00000584041 N/A N/A N/A N/A 0.270±0.00
ENST00000606895 1.761±0.33 5.636±0.74 2.019±0.00 N/A 0.997±0.69

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006GW CIL_0006GW_0001 CGP
CIL_0004WB CIL_0004WB_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0004519 IEA endonuclease activity
GO:0004521 IDA endoribonuclease activity
GO:0004540 IEA ribonuclease activity
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005637 IEA nuclear inner membrane
GO:0005739 IEA mitochondrion
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006397 IEA mRNA processing
GO:0006468 IDA:IEA protein phosphorylation
GO:0006987 IDA activation of signaling protein activity involved in unfolded protein response
GO:0007050 ISS cell cycle arrest
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019899 IPI enzyme binding
GO:0030176 IDA integral component of endoplasmic reticulum membrane
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0042802 IPI identical protein binding
GO:0044267 TAS cellular protein metabolic process
GO:0046777 IEA protein autophosphorylation
GO:0070055 IDA HAC1-type intron splice site recognition and cleavage
GO:0070059 IEA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis
GO:0090502 IDA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103 IMP positive regulation of endoplasmic reticulum unfolded protein response

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013997 ern1 protein_coding Danio_rerio
ENSMUSG00000020715 Ern1 protein_coding Mus_musculus

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