ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: solute carrier family 8 (sodium/calcium exchanger), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000183023 SLC8A1 9606 - 2:40097270-40611053 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332839 SLC8A1-201 40115253-40430280 protein_coding
  ENST00000402441 SLC8A1-006 40115113-40512435 protein_coding
  ENST00000403092 SLC8A1-010 40115031-40512361 protein_coding
  ENST00000405269 SLC8A1-012 40115250-40611053 protein_coding
  ENST00000405901 SLC8A1-003 40115045-40430304 protein_coding
  ENST00000406391 SLC8A1-202 40115253-40430280 protein_coding
  ENST00000406785 SLC8A1-005 40097270-40452069 protein_coding
  ENST00000407929 SLC8A1-011 40114731-40430271 nonsense_mediated_decay
  ENST00000408028 SLC8A1-013 40115253-40430280 protein_coding
  ENST00000417271 SLC8A1-009 40430061-40452008 protein_coding
  ENST00000448531 SLC8A1-008 40430020-40512435 protein_coding
  ENST00000455476 SLC8A1-004 40430020-40453438 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000402441ENST00000403092ENST00000405269ENST00000405901ENST00000406391ENST00000406785ENST00000407929ENST00000408028
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000402441 N/A N/A N/A 0.120±0.02
ENST00000403092 N/A N/A N/A 0.086±0.01
ENST00000405269 N/A 0.079±0.00 N/A 0.259±0.27
ENST00000405901 N/A N/A N/A 0.049±0.00
ENST00000406391 0.162±0.00 0.241±0.12 N/A 0.109±0.13
ENST00000406785 0.031±0.00 0.047±0.03 0.032±0.00 0.022±0.02
ENST00000407929 N/A 0.289±0.15 0.156±0.00 0.086±0.08
ENST00000408028 N/A 0.241±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00066Z CIL_00066Z_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001892 IEA embryonic placenta development
GO:0002026 ISS regulation of the force of heart contraction
GO:0002027 ISS regulation of heart rate
GO:0003007 IEA heart morphogenesis
GO:0005432 IDA:IEA calcium:sodium antiporter activity
GO:0005515 IEA protein binding
GO:0005516 IEA calmodulin binding
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006811 TAS ion transport
GO:0006814 IEA sodium ion transport
GO:0006816 IEA calcium ion transport
GO:0006883 IDA cellular sodium ion homeostasis
GO:0006936 TAS muscle contraction
GO:0007154 IEA cell communication
GO:0007596 TAS blood coagulation
GO:0008092 IDA cytoskeletal protein binding
GO:0009791 IEA post-embryonic development
GO:0010881 ISS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 TAS regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 ISS intercalated disc
GO:0014829 ISS vascular smooth muscle contraction
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016323 IEA basolateral plasma membrane
GO:0030018 ISS Z disc
GO:0030315 ISS T-tubule
GO:0030506 ISS ankyrin binding
GO:0034614 IDA cellular response to reactive oxygen species
GO:0035050 IEA embryonic heart tube development
GO:0035725 IEA sodium ion transmembrane transport
GO:0042383 ISS sarcolemma
GO:0044325 ISS ion channel binding
GO:0044557 ISS relaxation of smooth muscle
GO:0046872 IEA metal ion binding
GO:0048747 IEA muscle fiber development
GO:0051481 ISS negative regulation of cytosolic calcium ion concentration
GO:0055013 ISS cardiac muscle cell development
GO:0055074 ISS calcium ion homeostasis
GO:0055085 TAS:IEA transmembrane transport
GO:0055119 IC relaxation of cardiac muscle
GO:0060048 TAS cardiac muscle contraction
GO:0060401 TAS cytosolic calcium ion transport
GO:0060402 ISS calcium ion transport into cytosol
GO:0070509 IDA calcium ion import
GO:0071313 ISS cellular response to caffeine
GO:0071436 IDA sodium ion export
GO:0086012 TAS membrane depolarization during cardiac muscle cell action potential
GO:0086064 ISS cell communication by electrical coupling involved in cardiac conduction
GO:0097369 IDA sodium ion import
GO:1901660 IDA calcium ion export

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013422 slc8a1a protein_coding Danio_rerio
ENSDARG00000043406 slc8a1b protein_coding Danio_rerio
ENSMUSG00000054640 Slc8a1 protein_coding Mus_musculus

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