ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: protein kinase D1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184304 PRKD1 9606 - 14:29576479-30191898 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000331968 PRKD1-001 29576481-29927742 protein_coding
  ENST00000415220 PRKD1-002 29576942-29927642 protein_coding
  ENST00000468370 PRKD1-003 29638296-29666158 retained_intron
  ENST00000490795 PRKD1-004 29591115-29597668 nonsense_mediated_decay
  ENST00000546371 PRKD1-007 29630572-29634474 protein_coding
  ENST00000547441 PRKD1-005 29638523-29657844 processed_transcript
  ENST00000549503 PRKD1-008 29663812-30191898 protein_coding
  ENST00000551644 PRKD1-006 29636443-29650520 processed_transcript
  ENST00000616995 PRKD1-201 29576479-29927512 protein_coding
  ENST00000621126 PRKD1-202 29576479-29725678 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000331968ENST00000415220ENST00000549503ENST00000616995ENST00000621126
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000331968 N/A 1.128±0.57 1.647±0.00 1.214±0.44
ENST00000415220 N/A 0.723±0.12 N/A 0.497±0.19
ENST00000549503 N/A N/A N/A 3.034±0.00
ENST00000616995 0.946±0.00 0.674±0.20 N/A 1.155±0.48
ENST00000621126 0.569±0.00 1.944±0.36 2.272±0.00 1.148±0.54

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007XL CIL_0007XL_0001 VISTA
CIL_00099Q CIL_00099Q_0001 VISTA
CIL_0008M6 CIL_0008M6_0001 VISTA
CIL_00094H CIL_00094H_0001 VISTA
CIL_0008VR CIL_0008VR_0001 VISTA
CIL_00092M CIL_00092M_0001 VISTA
CIL_00095N CIL_00095N_0001 VISTA
CIL_0008C7 CIL_0008C7_0001 VISTA
CIL_0005EN CIL_0005EN_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001938 IGI positive regulation of endothelial cell proliferation
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004697 IEA protein kinase C activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005802 IDA trans-Golgi network
GO:0005829 ISS cytosol
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005938 IEA cell cortex
GO:0006468 IEA protein phosphorylation
GO:0006665 TAS sphingolipid metabolic process
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0007030 IMP Golgi organization
GO:0007165 TAS signal transduction
GO:0007229 TAS integrin-mediated signaling pathway
GO:0008283 TAS cell proliferation
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010837 ISS regulation of keratinocyte proliferation
GO:0010976 IMP positive regulation of neuron projection development
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0030148 TAS sphingolipid biosynthetic process
GO:0032793 IGI positive regulation of CREB transcription factor activity
GO:0033138 IGI positive regulation of peptidyl-serine phosphorylation
GO:0034599 IDA cellular response to oxidative stress
GO:0035556 IMP:IEA intracellular signal transduction
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038033 IMP positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042802 IPI identical protein binding
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 IMP positive regulation of blood vessel endothelial cell migration
GO:0044281 TAS small molecule metabolic process
GO:0045087 IEA innate immune response
GO:0045669 ISS positive regulation of osteoblast differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045806 TAS negative regulation of endocytosis
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046777 TAS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048193 ISS Golgi vesicle transport
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0060548 IMP negative regulation of cell death
GO:1901727 IGI positive regulation of histone deacetylase activity
GO:2001028 IMP positive regulation of endothelial cell chemotaxis
GO:2001044 TAS regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075949 prkd1 protein_coding Danio_rerio
ENSMUSG00000002688 Prkd1 protein_coding Mus_musculus

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