ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: zinc and ring finger 1, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186187 ZNRF1 9606 + 16:74999030-75110994 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000320619 ZNRF1-001 74999037-75108707 protein_coding
  ENST00000335325 ZNRF1-002 74999030-75110994 protein_coding
  ENST00000564320 ZNRF1-008 75000242-75107774 processed_transcript
  ENST00000566244 ZNRF1-004 75104060-75108039 retained_intron
  ENST00000566250 ZNRF1-003 74999345-75105005 protein_coding
  ENST00000567962 ZNRF1-007 74999345-75108028 protein_coding
  ENST00000568351 ZNRF1-010 75104784-75108590 protein_coding
  ENST00000568494 ZNRF1-005 75104798-75108004 retained_intron
  ENST00000568511 ZNRF1-009 75002297-75104889 protein_coding
  ENST00000568844 ZNRF1-006 75105383-75110713 retained_intron
  ENST00000579084 ZNRF1-012 75095144-75105336 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000320619ENST00000564320ENST00000566244ENST00000566250ENST00000567962ENST00000568351
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000320619 8.497±2.14 2.536±0.00 N/A N/A 8.213±2.80
ENST00000564320 32.876±0.00 N/A N/A N/A N/A
ENST00000566244 N/A N/A N/A N/A 3.364±1.66
ENST00000566250 N/A N/A N/A N/A 17.826±7.24
ENST00000567962 30.657±1.22 26.332±5.59 N/A 39.579±0.00 20.693±5.70
ENST00000568351 26.057±4.77 20.040±4.64 25.419±0.00 N/A 15.094±4.12

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002PJ CIL_0002PJ_0001 CGP
CIL_0002PH CIL_0002PH_0001 CGP
CIL_0004Y8 CIL_0004Y8_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005764 IEA lysosome
GO:0005768 IDA endosome
GO:0005829 IDA cytosol
GO:0008270 IEA zinc ion binding
GO:0016020 IDA membrane
GO:0016874 IEA ligase activity
GO:0030054 IEA cell junction
GO:0031410 IEA cytoplasmic vesicle
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045202 IEA synapse
GO:0046872 IEA metal ion binding
GO:0070936 ISS protein K48-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020475 znrf1 protein_coding Danio_rerio
ENSMUSG00000033545 Znrf1 protein_coding Mus_musculus

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