ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: MKL/myocardin-like 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186260 MKL2 9606 + 16:14071321-14266773 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000318282 MKL2-201 14079288-14266772 protein_coding
  ENST00000571589 MKL2-001 14071322-14266771 protein_coding
  ENST00000571770 MKL2-012 14258123-14262440 nonsense_mediated_decay
  ENST00000572400 MKL2-003 14071322-14144785 retained_intron
  ENST00000572567 MKL2-004 14186717-14241425 protein_coding
  ENST00000572588 MKL2-006 14247411-14266773 retained_intron
  ENST00000573051 MKL2-005 14200330-14241468 protein_coding
  ENST00000573434 MKL2-010 14140625-14170470 protein_coding
  ENST00000574045 MKL2-002 14071339-14261448 protein_coding
  ENST00000574998 MKL2-007 14071321-14210298 protein_coding
  ENST00000575537 MKL2-009 14071344-14149536 processed_transcript
  ENST00000575768 MKL2-011 14140633-14214935 processed_transcript
  ENST00000575833 MKL2-008 14092837-14141529 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000318282ENST00000571589ENST00000572400ENST00000572588ENST00000574045
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000318282 N/A 0.403±0.00 N/A N/A 0.927±0.22
ENST00000571589 N/A 3.455±0.64 N/A 1.833±0.00 3.963±1.92
ENST00000572400 N/A N/A N/A N/A 3.011±0.00
ENST00000572588 0.419±0.00 N/A 0.543±0.00 N/A 2.005±0.56
ENST00000574045 N/A N/A N/A N/A 2.800±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0002RP CIL_0002RP_0002 CGP
CIL_0007DW CIL_0007DW_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0003007 IEA heart morphogenesis
GO:0003676 IEA nucleic acid binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0003779 IEA actin binding
GO:0005515 IPI protein binding
GO:0005634 IC nucleus
GO:0005737 IEA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0007507 IEA heart development
GO:0007517 IEA muscle organ development
GO:0010467 IEA gene expression
GO:0010468 IEA regulation of gene expression
GO:0045844 IDA positive regulation of striated muscle tissue development
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048514 IEA blood vessel morphogenesis
GO:0048568 IEA embryonic organ development
GO:0048738 IEA cardiac muscle tissue development
GO:0051145 IEA smooth muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076867 mkl2b protein_coding Danio_rerio
ENSDARG00000088307 mkl2a protein_coding Danio_rerio
ENSMUSG00000009569 Mkl2 protein_coding Mus_musculus

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