ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: beta-site APP-cleaving enzyme 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186318 BACE1 9606 - 11:117285207-117316259 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000313005 BACE1-001 117285207-117316256 protein_coding
  ENST00000392937 BACE1-006 117285706-117295636 protein_coding
  ENST00000428381 BACE1-002 117289535-117315798 protein_coding
  ENST00000445823 BACE1-004 117289535-117315798 protein_coding
  ENST00000504995 BACE1-008 117293071-117299696 protein_coding
  ENST00000509916 BACE1-010 117290503-117291997 retained_intron
  ENST00000510630 BACE1-007 117289487-117295573 protein_coding
  ENST00000510915 BACE1-009 117291799-117295485 protein_coding
  ENST00000513780 BACE1-003 117289535-117315798 protein_coding
  ENST00000514464 BACE1-005 117293871-117315795 processed_transcript
  ENST00000528053 BACE1-013 117287351-117316259 protein_coding
  ENST00000530824 BACE1-016 117290634-117294441 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000313005ENST00000392937ENST00000510630ENST00000513780ENST00000528053
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000313005 2.818±0.00 4.339±1.14 4.160±0.00 3.529±1.90
ENST00000392937 N/A 5.106±1.68 3.226±0.00 5.197±2.05
ENST00000510630 N/A N/A N/A 6.155±0.00
ENST00000513780 N/A N/A N/A 6.910±0.00
ENST00000528053 1.220±0.00 7.788±1.41 7.555±0.00 5.342±1.87

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0004175 IEA endopeptidase activity
GO:0004190 IEA:IDA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005770 IDA late endosome
GO:0005771 IDA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA:IDA proteolysis
GO:0006509 TAS membrane protein ectodomain proteolysis
GO:0008233 IEA peptidase activity
GO:0008798 TAS beta-aspartyl-peptidase activity
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0019899 IPI enzyme binding
GO:0030424 IEA axon
GO:0031410 IEA cytoplasmic vesicle
GO:0050435 IDA beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000032086 Bace1 protein_coding Mus_musculus

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