ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: beta-site APP-cleaving enzyme 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000313005 BACE1-001 ENSG00000186318 9606 - 11:117285207-117316256 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000313005
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000313005 2.818±0.00 4.339±1.14 4.160±0.00 3.529±1.90

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0004175 IEA endopeptidase activity
GO:0004190 IEA:IDA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005768 IDA endosome
GO:0005770 IDA late endosome
GO:0005771 IDA multivesicular body
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006508 IEA:IDA proteolysis
GO:0006509 TAS membrane protein ectodomain proteolysis
GO:0008233 IEA peptidase activity
GO:0008798 TAS beta-aspartyl-peptidase activity
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0019899 IPI enzyme binding
GO:0030424 IEA axon
GO:0031410 IEA cytoplasmic vesicle
GO:0050435 IDA beta-amyloid metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034591 Bace1-001 protein_coding Mus_musculus 0 2615
ENSMUST00000159970 Bace1-003 retained_intron Mus_musculus 0 1668
ENSMUST00000078111 Bace1-002 protein_coding Mus_musculus 0 1291
ENSMUST00000162587 Bace1-006 protein_coding Mus_musculus 0 1242
ENSMUST00000058720 Rnf214-001 protein_coding Mus_musculus 0 710
ENSMUST00000161187 Rnf214-005 protein_coding Mus_musculus 0 710
ENSMUST00000161203 Rnf214-003 protein_coding Mus_musculus 0 710
ENSMUST00000162369 Rnf214-006 retained_intron Mus_musculus 0 503
ENSMUST00000162699 Rnf214-004 nonsense_mediated_decay Mus_musculus 0 497
ENSMUST00000162559 Bace1-005 processed_transcript Mus_musculus 0 255
ENSMUST00000159499 Bace1-004 nonsense_mediated_decay Mus_musculus 0 235

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