ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: peroxisome proliferator-activated receptor alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186951 PPARA 9606 + 22:46150521-46243756 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262735 PPARA-201 46150596-46243756 protein_coding
  ENST00000402126 PPARA-008 46176748-46235403 protein_coding
  ENST00000407236 PPARA-001 46151884-46243755 protein_coding
  ENST00000415785 PPARA-009 46150552-46198591 protein_coding
  ENST00000420804 PPARA-003 46150606-46215364 protein_coding
  ENST00000440343 PPARA-002 46150521-46198410 protein_coding
  ENST00000460086 PPARA-004 46150828-46151970 processed_transcript
  ENST00000481567 PPARA-006 46171332-46198410 processed_transcript
  ENST00000484619 PPARA-007 46171284-46198410 processed_transcript
  ENST00000493286 PPARA-005 46176766-46220657 retained_intron
  ENST00000496865 PPARA-010 46151886-46156593 processed_transcript
  ENST00000624793 PPARA-011 46154997-46156552 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000262735ENST00000407236ENST00000493286
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000262735 N/A 0.841±0.60 1.099±0.00 N/A 0.785±0.51
ENST00000407236 N/A 0.943±0.55 N/A 2.083±0.00 0.680±0.45
ENST00000493286 0.971±0.00 0.724±0.03 N/A N/A 0.564±0.13

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0001Q1 CIL_0001Q1_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001190 IEA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001666 IEA response to hypoxia
GO:0003677 TAS DNA binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IDA:IEA steroid hormone receptor activity
GO:0004872 IEA receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006629 TAS lipid metabolic process
GO:0006631 IEA fatty acid metabolic process
GO:0007507 IEA heart development
GO:0008144 IDA drug binding
GO:0008270 IEA zinc ion binding
GO:0008289 IDA lipid binding
GO:0008544 IEA epidermis development
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010871 IDA negative regulation of receptor biosynthetic process
GO:0010887 IDA negative regulation of cholesterol storage
GO:0010891 IDA negative regulation of sequestering of triglyceride
GO:0015908 TAS fatty acid transport
GO:0019217 IEA regulation of fatty acid metabolic process
GO:0019902 IEA phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031624 IPI ubiquitin conjugating enzyme binding
GO:0032000 TAS positive regulation of fatty acid beta-oxidation
GO:0032091 IEA negative regulation of protein binding
GO:0032099 ISS negative regulation of appetite
GO:0032403 IEA protein complex binding
GO:0032868 IEA response to insulin
GO:0032922 ISS circadian regulation of gene expression
GO:0035095 IEA behavioral response to nicotine
GO:0042060 IEA wound healing
GO:0042157 IEA lipoprotein metabolic process
GO:0042752 ISS regulation of circadian rhythm
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 ISS:IEA sequence-specific DNA binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0045776 IEA negative regulation of blood pressure
GO:0045820 IC negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046321 ISS positive regulation of fatty acid oxidation
GO:0051525 IEA NFAT protein binding
GO:0070166 IEA enamel mineralization
GO:0072363 IDA regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072366 IDA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IDA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0097371 IEA MDM2/MDM4 family protein binding
GO:1901215 IEA negative regulation of neuron death
GO:2000678 IEA negative regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031777 pparaa protein_coding Danio_rerio
ENSDARG00000054323 pparab protein_coding Danio_rerio
ENSMUSG00000022383 Ppara protein_coding Mus_musculus

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