ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: peroxisome proliferator-activated receptor alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000407236 PPARA-001 ENSG00000186951 9606 + 22:46151884-46243755 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000407236
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000407236 0.943±0.55 2.083±0.00 0.680±0.45

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103 IPI RNA polymerase II repressing transcription factor binding
GO:0001190 IEA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001666 IEA response to hypoxia
GO:0003677 TAS DNA binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IDA:IEA steroid hormone receptor activity
GO:0004872 IEA receptor activity
GO:0004879 IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006629 TAS lipid metabolic process
GO:0006631 IEA fatty acid metabolic process
GO:0007507 IEA heart development
GO:0008144 IDA drug binding
GO:0008270 IEA zinc ion binding
GO:0008289 IDA lipid binding
GO:0008544 IEA epidermis development
GO:0010467 TAS gene expression
GO:0010468 IEA regulation of gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010871 IDA negative regulation of receptor biosynthetic process
GO:0010887 IDA negative regulation of cholesterol storage
GO:0010891 IDA negative regulation of sequestering of triglyceride
GO:0015908 TAS fatty acid transport
GO:0019217 IEA regulation of fatty acid metabolic process
GO:0019902 IEA phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031624 IPI ubiquitin conjugating enzyme binding
GO:0032000 TAS positive regulation of fatty acid beta-oxidation
GO:0032091 IEA negative regulation of protein binding
GO:0032099 ISS negative regulation of appetite
GO:0032403 IEA protein complex binding
GO:0032868 IEA response to insulin
GO:0032922 ISS circadian regulation of gene expression
GO:0035095 IEA behavioral response to nicotine
GO:0042060 IEA wound healing
GO:0042157 IEA lipoprotein metabolic process
GO:0042752 ISS regulation of circadian rhythm
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 ISS:IEA sequence-specific DNA binding
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0045776 IEA negative regulation of blood pressure
GO:0045820 IC negative regulation of glycolytic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046321 ISS positive regulation of fatty acid oxidation
GO:0051525 IEA NFAT protein binding
GO:0070166 IEA enamel mineralization
GO:0072363 IDA regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072366 IDA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IDA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0097371 IEA MDM2/MDM4 family protein binding
GO:1901215 IEA negative regulation of neuron death
GO:2000678 IEA negative regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000057979 Ppara-003 protein_coding Mus_musculus 0 1474
ENSMUST00000109423 Ppara-002 protein_coding Mus_musculus 0 1474
ENSMUST00000109422 Ppara-001 protein_coding Mus_musculus 0 1474
ENSDART00000123458 pparda-201 protein_coding Danio_rerio 0 329
ENSDART00000149743 pparda-001 protein_coding Danio_rerio 0 329
ENSMUST00000038014 Dnajc16-001 protein_coding Mus_musculus 0.00000000004 77

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