ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197594 ENPP1 9606 + 6:131808016-131895155 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360971 ENPP1-001 131808016-131895155 protein_coding
  ENST00000459624 ENPP1-002 131861610-131877857 retained_intron
  ENST00000486853 ENPP1-003 131808016-131851423 retained_intron
  ENST00000513998 ENPP1-004 131808034-131890864 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000360971ENST00000459624ENST00000486853ENST00000513998
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000360971 0.094±0.04 1.206±0.61 0.177±0.00 0.067±0.00 0.236±0.18
ENST00000459624 N/A N/A 0.237±0.00 0.318±0.00 0.184±0.13
ENST00000486853 N/A N/A N/A N/A 0.351±0.00
ENST00000513998 N/A 1.184±0.53 N/A 0.094±0.00 0.198±0.10

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00097U CIL_00097U_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003824 IEA catalytic activity
GO:0004528 ISS phosphodiesterase I activity
GO:0004551 IDA nucleotide diphosphatase activity
GO:0005044 IEA scavenger receptor activity
GO:0005158 IDA insulin receptor binding
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005615 IDA extracellular space
GO:0005765 IDA lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006091 IDA generation of precursor metabolites and energy
GO:0006200 ISS ATP catabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0006771 TAS riboflavin metabolic process
GO:0006796 IDA phosphate-containing compound metabolic process
GO:0006898 IEA receptor-mediated endocytosis
GO:0006955 IEA immune response
GO:0008152 IEA metabolic process
GO:0008270 ISS zinc ion binding
GO:0009143 IDA nucleoside triphosphate catabolic process
GO:0009986 IDA cell surface
GO:0016021 ISS integral component of membrane
GO:0016323 NAS basolateral plasma membrane
GO:0016787 IEA hydrolase activity
GO:0030247 IEA polysaccharide binding
GO:0030279 IEA negative regulation of ossification
GO:0030308 IDA negative regulation of cell growth
GO:0030500 IC regulation of bone mineralization
GO:0030505 IDA inorganic diphosphate transport
GO:0030643 IDA cellular phosphate ion homeostasis
GO:0030730 IDA sequestering of triglyceride
GO:0031214 IEA biomineral tissue development
GO:0031953 IDA negative regulation of protein autophosphorylation
GO:0032869 IDA cellular response to insulin stimulus
GO:0035529 IEA NADH pyrophosphatase activity
GO:0042803 IDA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0045599 IDA negative regulation of fat cell differentiation
GO:0045719 IDA negative regulation of glycogen biosynthetic process
GO:0046325 IDA negative regulation of glucose import
GO:0046627 IDA negative regulation of insulin receptor signaling pathway
GO:0046849 IEA bone remodeling
GO:0046872 IEA metal ion binding
GO:0047429 IDA nucleoside-triphosphate diphosphatase activity
GO:0050427 IDA 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050656 IC 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005789 enpp1 protein_coding Danio_rerio
ENSMUSG00000037370 Enpp1 protein_coding Mus_musculus

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