ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: ectonucleotide pyrophosphatase/phosphodiesterase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000360971 ENPP1-001 ENSG00000197594 9606 + 6:131808016-131895155 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000360971
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000360971 0.094±0.04 1.206±0.61 0.177±0.00 0.067±0.00 0.236±0.18

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003824 IEA catalytic activity
GO:0004528 ISS phosphodiesterase I activity
GO:0004551 IDA nucleotide diphosphatase activity
GO:0005044 IEA scavenger receptor activity
GO:0005158 IDA insulin receptor binding
GO:0005509 ISS calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005615 IDA extracellular space
GO:0005765 IDA lysosomal membrane
GO:0005886 IDA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0006091 IDA generation of precursor metabolites and energy
GO:0006200 ISS ATP catabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0006771 TAS riboflavin metabolic process
GO:0006796 IDA phosphate-containing compound metabolic process
GO:0006898 IEA receptor-mediated endocytosis
GO:0006955 IEA immune response
GO:0008152 IEA metabolic process
GO:0008270 ISS zinc ion binding
GO:0009143 IDA nucleoside triphosphate catabolic process
GO:0009986 IDA cell surface
GO:0016021 ISS integral component of membrane
GO:0016323 NAS basolateral plasma membrane
GO:0016787 IEA hydrolase activity
GO:0030247 IEA polysaccharide binding
GO:0030279 IEA negative regulation of ossification
GO:0030308 IDA negative regulation of cell growth
GO:0030500 IC regulation of bone mineralization
GO:0030505 IDA inorganic diphosphate transport
GO:0030643 IDA cellular phosphate ion homeostasis
GO:0030730 IDA sequestering of triglyceride
GO:0031214 IEA biomineral tissue development
GO:0031953 IDA negative regulation of protein autophosphorylation
GO:0032869 IDA cellular response to insulin stimulus
GO:0035529 IEA NADH pyrophosphatase activity
GO:0042803 IDA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0045599 IDA negative regulation of fat cell differentiation
GO:0045719 IDA negative regulation of glycogen biosynthetic process
GO:0046325 IDA negative regulation of glucose import
GO:0046627 IDA negative regulation of insulin receptor signaling pathway
GO:0046849 IEA bone remodeling
GO:0046872 IEA metal ion binding
GO:0047429 IDA nucleoside-triphosphate diphosphatase activity
GO:0050427 IDA 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0050656 IC 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105520 Enpp1-001 protein_coding Mus_musculus 0 2187
ENSMUST00000135846 Enpp1-002 protein_coding Mus_musculus 0 2172
ENSMUST00000150570 Enpp1-004 retained_intron Mus_musculus 0 1845
ENSMUST00000039882 Enpp1-003 nonsense_mediated_decay Mus_musculus 0 1221
ENSMUST00000024742 Nfkbie-201 protein_coding Mus_musculus 0.0000008 62
ENSMUST00000034431 Tmem170-201 protein_coding Mus_musculus 0.0000008 62

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