ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: aspartate beta-hydroxylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198363 ASPH 9606 - 8:61500556-61714640 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356457 ASPH-001 61623710-61714596 protein_coding
  ENST00000379449 ASPH-006 61675259-61714546 protein_coding
  ENST00000379454 ASPH-002 61500556-61714559 protein_coding
  ENST00000389204 ASPH-005 61664725-61689774 protein_coding
  ENST00000445642 ASPH-201 61623710-61714640 protein_coding
  ENST00000517661 ASPH-015 61675878-61689775 protein_coding
  ENST00000517847 ASPH-032 61625306-61689768 protein_coding
  ENST00000517856 ASPH-018 61656128-61714587 protein_coding
  ENST00000517903 ASPH-003 61624603-61689779 protein_coding
  ENST00000517928 ASPH-013 61661814-61684700 processed_transcript
  ENST00000518068 ASPH-008 61624539-61714568 protein_coding
  ENST00000518306 ASPH-016 61637969-61689849 protein_coding
  ENST00000518441 ASPH-020 61625645-61638046 retained_intron
  ENST00000519234 ASPH-011 61624537-61714525 protein_coding
  ENST00000519264 ASPH-022 61633125-61637986 protein_coding
  ENST00000519678 ASPH-021 61626141-61646872 protein_coding
  ENST00000520198 ASPH-019 61644600-61651431 retained_intron
  ENST00000521499 ASPH-026 61576601-61637999 retained_intron
  ENST00000521909 ASPH-025 61517013-61526086 retained_intron
  ENST00000522036 ASPH-017 61683553-61689699 retained_intron
  ENST00000522325 ASPH-014 61680524-61684190 retained_intron
  ENST00000522343 ASPH-012 61687415-61689715 processed_transcript
  ENST00000522349 ASPH-024 61576772-61689811 protein_coding
  ENST00000522603 ASPH-004 61665140-61689786 protein_coding
  ENST00000522835 ASPH-009 61625910-61689812 protein_coding
  ENST00000522919 ASPH-023 61606461-61646807 protein_coding
  ENST00000523897 ASPH-027 61582999-61643417 processed_transcript
  ENST00000523927 ASPH-029 61583944-61680999 protein_coding
  ENST00000524173 ASPH-028 61567257-61651086 protein_coding
  ENST00000541428 ASPH-202 61500557-61689849 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000379454ENST00000445642ENST00000517856ENST00000517903ENST00000518068ENST00000519234ENST00000541428
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000379454 N/A 13.850±2.75 41.984±0.00 11.927±7.98
ENST00000445642 N/A N/A N/A 2.098±0.00
ENST00000517856 N/A 5.122±0.73 N/A 3.681±1.39
ENST00000517903 N/A N/A N/A 5.460±0.88
ENST00000518068 10.778±0.00 11.318±2.27 23.215±0.00 12.447±8.05
ENST00000519234 6.385±0.00 14.145±3.34 23.254±0.00 N/A
ENST00000541428 N/A N/A N/A 3.460±0.68

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003FX CIL_0003FX_0001 CGP
CIL_0003GG CIL_0003GG_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004597 IEA peptide-aspartate beta-dioxygenase activity
GO:0005198 TAS structural molecule activity
GO:0005509 NAS calcium ion binding
GO:0005513 TAS detection of calcium ion
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 NAS endoplasmic reticulum membrane
GO:0005886 IDA plasma membrane
GO:0006936 TAS muscle contraction
GO:0007389 IEA pattern specification process
GO:0008285 IEA negative regulation of cell proliferation
GO:0008307 TAS structural constituent of muscle
GO:0009055 TAS electron carrier activity
GO:0010524 IDA positive regulation of calcium ion transport into cytosol
GO:0010649 TAS regulation of cell communication by electrical coupling
GO:0010880 TAS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 ISS regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014701 TAS junctional sarcoplasmic reticulum membrane
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0018193 IEA peptidyl-amino acid modification
GO:0030176 IDA integral component of endoplasmic reticulum membrane
GO:0031585 IDA regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031647 IEA regulation of protein stability
GO:0032237 IDA activation of store-operated calcium channel activity
GO:0032541 IDA cortical endoplasmic reticulum
GO:0033017 TAS sarcoplasmic reticulum membrane
GO:0033018 TAS sarcoplasmic reticulum lumen
GO:0033198 IDA response to ATP
GO:0034704 TAS calcium channel complex
GO:0035108 IEA limb morphogenesis
GO:0042264 IEA peptidyl-aspartic acid hydroxylation
GO:0044325 TAS ion channel binding
GO:0045862 IDA positive regulation of proteolysis
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0055114 IEA oxidation-reduction process
GO:0060021 IEA palate development
GO:0060314 TAS regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 TAS positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0060325 IEA face morphogenesis
GO:0070588 IDA calcium ion transmembrane transport
GO:0071277 IDA cellular response to calcium ion
GO:0090316 IDA positive regulation of intracellular protein transport
GO:0097202 IDA activation of cysteine-type endopeptidase activity
GO:1901879 IEA regulation of protein depolymerization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078703 ASPH protein_coding Danio_rerio
ENSMUSG00000028207 Asph protein_coding Mus_musculus

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