ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: programmed cell death 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000249915 PDCD6 9606 + 5:271621-353856 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264933 PDCD6-001 271621-314974 protein_coding
  ENST00000505221 PDCD6-011 271647-314806 protein_coding
  ENST00000505526 PDCD6-002 271661-312411 nonsense_mediated_decay
  ENST00000506909 PDCD6-014 271670-353856 nonsense_mediated_decay
  ENST00000507473 PDCD6-012 272712-314686 protein_coding
  ENST00000507528 PDCD6-008 271657-314969 protein_coding
  ENST00000509581 PDCD6-006 271657-276940 protein_coding
  ENST00000511482 PDCD6-009 306681-314954 processed_transcript
  ENST00000512466 PDCD6-007 308197-314973 retained_intron
  ENST00000513582 PDCD6-003 271625-314969 retained_intron
  ENST00000515587 PDCD6-005 271624-273367 retained_intron
  ENST00000614778 PDCD6-201 271621-314974 protein_coding
  ENST00000618970 PDCD6-202 271621-314974 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000264933ENST00000507473ENST00000507528ENST00000511482ENST00000512466ENST00000513582ENST00000614778ENST00000618970
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000264933 20.138±0.00 21.432±14.78 N/A 34.486±0.00 40.144±29.32
ENST00000507473 N/A 56.163±0.00 N/A N/A N/A
ENST00000507528 27.859±0.00 38.444±11.54 N/A 25.703±0.00 18.896±10.46
ENST00000511482 18.828±0.00 N/A 24.798±0.00 N/A N/A
ENST00000512466 N/A 1.320±0.03 N/A N/A 4.859±0.00
ENST00000513582 N/A 1.539±0.04 N/A N/A 1.880±0.26
ENST00000614778 22.441±2.96 48.706±15.87 N/A N/A 17.888±6.00
ENST00000618970 20.560±0.00 23.943±0.03 29.517±0.00 N/A 22.897±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0004198 IBA calcium-dependent cysteine-type endopeptidase activity
GO:0005509 ISS:IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0006508 IBA proteolysis
GO:0006886 IDA intracellular protein transport
GO:0006915 IEA apoptotic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0016020 IEA membrane
GO:0030948 IDA negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031410 IDA cytoplasmic vesicle
GO:0032007 IDA negative regulation of TOR signaling
GO:0034605 IDA cellular response to heat
GO:0036324 IDA vascular endothelial growth factor receptor-2 signaling pathway
GO:0042803 IEA protein homodimerization activity
GO:0045766 IDA positive regulation of angiogenesis
GO:0046983 IPI protein dimerization activity
GO:0048306 IPI calcium-dependent protein binding
GO:0051592 ISS response to calcium ion
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0060090 IMP binding, bridging
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005220 pdcd6 protein_coding Danio_rerio
ENSMUSG00000021576 Pdcd6 protein_coding Mus_musculus

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