ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000049313 Sorl1 10090 - 9:41964720-42124297 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000060989 Sorl1-001 41964720-42124297 protein_coding
  ENSMUST00000134560 Sorl1-004 41969739-41974587 retained_intron
  ENSMUST00000139133 Sorl1-002 41984508-41985834 processed_transcript
  ENSMUST00000148800 Sorl1-003 41977562-41984570 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000060989ENSMUST00000148800
Transcript ID C166 Tie2+ EC mES
ENSMUST00000060989 0.593±0.20 0.041±0.02 0.238±0.09
ENSMUST00000148800 N/A 0.315±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008XM CIL_0008XM_0002 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000042 ISS protein targeting to Golgi
GO:0001540 IEA beta-amyloid binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005641 IDA nuclear envelope lumen
GO:0005768 IEA endosome
GO:0005769 ISS early endosome
GO:0005771 IEA multivesicular body
GO:0005783 ISS endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005802 ISS trans-Golgi network
GO:0006605 ISS protein targeting
GO:0006622 ISS protein targeting to lysosome
GO:0006869 IEA lipid transport
GO:0006892 ISS post-Golgi vesicle-mediated transport
GO:0006897 IEA endocytosis
GO:0008203 IEA cholesterol metabolic process
GO:0008283 IEA cell proliferation
GO:0014910 IEA regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016477 IEA cell migration
GO:0030169 IEA low-density lipoprotein particle binding
GO:0030306 IEA ADP-ribosylation factor binding
GO:0031985 ISS Golgi cisterna
GO:0032091 ISS negative regulation of protein binding
GO:0032460 ISS negative regulation of protein oligomerization
GO:0034362 IEA low-density lipoprotein particle
GO:0043025 IEA neuronal cell body
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0045053 IMP protein retention in Golgi apparatus
GO:0045732 ISS positive regulation of protein catabolic process
GO:0048471 ISO perinuclear region of cytoplasm
GO:0050768 IMP negative regulation of neurogenesis
GO:0051604 ISS protein maturation
GO:0055037 ISS recycling endosome
GO:0070062 IEA extracellular vesicular exosome
GO:0070863 ISS positive regulation of protein exit from endoplasmic reticulum
GO:1901215 IMP negative regulation of neuron death
GO:1902430 IMP negative regulation of beta-amyloid formation
GO:1902771 IMP positive regulation of choline O-acetyltransferase activity
GO:1902948 IMP negative regulation of tau-protein kinase activity
GO:1902953 ISS positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 ISS positive regulation of early endosome to recycling endosome transport
GO:1902960 IMP negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 IMP negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 ISS positive regulation of protein localization to early endosome
GO:1902997 IMP negative regulation of neurofibrillary tangle assembly
GO:2001137 ISS positive regulation of endocytic recycling

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013892 sorl1 protein_coding Danio_rerio
ENSG00000137642 SORL1 sortilin-related receptor, L(DLR class) A repeats containing protein_coding Homo_sapiens

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