ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000052593 Adam17 10090 - 12:21323509-21373632 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000064536 Adam17-001 21323517-21373632 protein_coding
  ENSMUST00000101551 Adam17-002 21323509-21373593 protein_coding
  ENSMUST00000127974 Adam17-003 21323517-21373593 nonsense_mediated_decay
  ENSMUST00000132339 Adam17-008 21330073-21332521 retained_intron
  ENSMUST00000141799 Adam17-005 21325526-21329290 processed_transcript
  ENSMUST00000142092 Adam17-009 21349903-21373534 nonsense_mediated_decay
  ENSMUST00000145118 Adam17-007 21323517-21373593 nonsense_mediated_decay
  ENSMUST00000155115 Adam17-004 21327980-21344229 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000064536ENSMUST00000101551
Transcript ID C166 Tie2+ EC mES
ENSMUST00000064536 25.210±4.84 16.578±3.27 8.145±1.75
ENSMUST00000101551 N/A N/A 1.081±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00057M CIL_00057M_0002 CGP
CIL_0007AU CIL_0007AU_0003 CGP
CIL_0001MI CIL_0001MI_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002467 IMP germinal center formation
GO:0004222 TAS metalloendopeptidase activity
GO:0005112 ISS Notch binding
GO:0005138 IEA interleukin-6 receptor binding
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005925 IEA focal adhesion
GO:0006508 ISS proteolysis
GO:0006509 IMP membrane protein ectodomain proteolysis
GO:0007155 IEA cell adhesion
GO:0007173 IEA epidermal growth factor receptor signaling pathway
GO:0007219 IEA Notch signaling pathway
GO:0007220 ISS Notch receptor processing
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0009986 IEA cell surface
GO:0010820 IEA positive regulation of T cell chemotaxis
GO:0015629 IEA actin cytoskeleton
GO:0016020 IEA membrane
GO:0016324 IEA apical plasma membrane
GO:0017124 IEA SH3 domain binding
GO:0030165 IEA PDZ domain binding
GO:0030183 IMP B cell differentiation
GO:0030307 IEA positive regulation of cell growth
GO:0030335 IEA positive regulation of cell migration
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031659 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032496 IEA response to lipopolysaccharide
GO:0032587 IEA ruffle membrane
GO:0032717 IEA negative regulation of interleukin-8 production
GO:0032722 IEA positive regulation of chemokine production
GO:0033025 IMP regulation of mast cell apoptotic process
GO:0033077 IMP T cell differentiation in thymus
GO:0033627 IEA cell adhesion mediated by integrin
GO:0035313 IEA wound healing, spreading of epidermal cells
GO:0035625 IEA epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493 IMP response to drug
GO:0045121 IEA membrane raft
GO:0045741 IEA positive regulation of epidermal growth factor-activated receptor activity
GO:0048536 IMP spleen development
GO:0048870 IMP cell motility
GO:0051088 IDA PMA-inducible membrane protein ectodomain proteolysis
GO:0051272 IMP positive regulation of cellular component movement
GO:0055099 IEA response to high density lipoprotein particle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043213 adam17a protein_coding Danio_rerio
ENSDARG00000093093 adam17b protein_coding Danio_rerio
ENSG00000151694 ADAM17 ADAM metallopeptidase domain 17 protein_coding Homo_sapiens

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