ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000074934 Grem1 10090 - 2:113746164-113758646 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000099575 Grem1-001 113746164-113758646 protein_coding

Mus musculus Ensembl GRCm38

Genome
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Sequences
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Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000099575
Transcript ID C166 Tie2+ EC mES
ENSMUST00000099575 0.895±0.43 0.018±0.01 0.013±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00097N CIL_00097N_0002 VISTA
CIL_0000Z5 CIL_0000Z5_0003 CGP
CIL_00065T CIL_00065T_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IEA cell morphogenesis
GO:0001525 IDA angiogenesis
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0002042 IDA cell migration involved in sprouting angiogenesis
GO:0002092 IDA positive regulation of receptor internalization
GO:0002689 IEA negative regulation of leukocyte chemotaxis
GO:0003257 IDA positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337 IDA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 IEA cytokine activity
GO:0005515 IEA protein binding
GO:0005615 IDA extracellular space
GO:0006915 IEA apoptotic process
GO:0007165 IDA signal transduction
GO:0007171 IDA activation of transmembrane receptor protein tyrosine kinase activity
GO:0007267 IMP cell-cell signaling
GO:0008284 IEA positive regulation of cell proliferation
GO:0009887 IMP organ morphogenesis
GO:0009954 IMP proximal/distal pattern formation
GO:0009986 IDA cell surface
GO:0010717 IEA regulation of epithelial to mesenchymal transition
GO:0030199 IEA collagen fibril organization
GO:0030297 IDA transmembrane receptor protein tyrosine kinase activator activity
GO:0030308 IEA negative regulation of cell growth
GO:0030326 IMP embryonic limb morphogenesis
GO:0030502 IEA negative regulation of bone mineralization
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0033689 IEA negative regulation of osteoblast proliferation
GO:0042346 IDA positive regulation of NF-kappaB import into nucleus
GO:0043184 IPI vascular endothelial growth factor receptor 2 binding
GO:0043395 TAS heparan sulfate proteoglycan binding
GO:0043542 IDA endothelial cell migration
GO:0045766 IMP positive regulation of angiogenesis
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046851 IEA negative regulation of bone remodeling
GO:0048018 IPI receptor agonist activity
GO:0048263 IEA determination of dorsal identity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051893 IDA regulation of focal adhesion assembly
GO:0051973 IEA positive regulation of telomerase activity
GO:0060394 IEA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676 IDA ureteric bud formation
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:0090027 IEA negative regulation of monocyte chemotaxis
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090190 IDA positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191 IDA negative regulation of branching involved in ureteric bud morphogenesis
GO:0090291 IEA negative regulation of osteoclast proliferation
GO:1900086 IDA positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155 IEA negative regulation of bone trabecula formation
GO:1900158 IEA negative regulation of bone mineralization involved in bone maturation
GO:2000273 IDA positive regulation of receptor activity
GO:2000727 IDA positive regulation of cardiac muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029546 grem1a protein_coding Danio_rerio
ENSDARG00000090720 grem1a protein_coding Danio_rerio
ENSG00000166923 GREM1 gremlin 1, DAN family BMP antagonist protein_coding Homo_sapiens

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