ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: tuberous sclerosis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000219476 TSC2-001 ENSG00000103197 9606 + 16:2047465-2088712 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HUVECENST00000219476
Transcript ID HUVEC
ENST00000219476 4.911±0.86

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001843 ISS neural tube closure
GO:0005096 IDA:IEA GTPase activator activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005856 IEA cytoskeleton
GO:0005901 IEA caveola
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006606 ISS protein import into nucleus
GO:0006897 TAS endocytosis
GO:0006953 IEA acute-phase response
GO:0007050 TAS cell cycle arrest
GO:0007165 IEA signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007507 ISS heart development
GO:0008104 ISS protein localization
GO:0008285 ISS negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0014067 ISS negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016192 TAS vesicle-mediated transport
GO:0019902 IDA phosphatase binding
GO:0030030 IEA cell projection organization
GO:0030100 ISS regulation of endocytosis
GO:0030178 IBA negative regulation of Wnt signaling pathway
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0032007 IBA negative regulation of TOR signaling
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032869 IEA cellular response to insulin stimulus
GO:0033596 IDA TSC1-TSC2 complex
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0043491 ISS protein kinase B signaling
GO:0043547 IEA positive regulation of GTPase activity
GO:0044861 IEA protein transport into plasma membrane raft
GO:0045087 TAS innate immune response
GO:0045121 IEA membrane raft
GO:0045184 IEA establishment of protein localization
GO:0045792 IEA negative regulation of cell size
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046323 IEA glucose import
GO:0046626 ISS regulation of insulin receptor signaling pathway
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0046982 IEA protein heterodimerization activity
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050918 ISS positive chemotaxis
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051260 IEA protein homooligomerization
GO:0051291 IEA protein heterooligomerization
GO:0051726 IBA regulation of cell cycle
GO:0051898 ISS negative regulation of protein kinase B signaling
GO:0071889 IEA 14-3-3 protein binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000097373 Tsc2-201 protein_coding Mus_musculus 0 3181

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