ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: mutS homolog 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000233146 MSH2-001 ENSG00000095002 9606 + 2:47402969-47483228 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000233146
Transcript ID BECs HAoEC HUVEC
ENST00000233146 0.534±0.00 2.326±1.06 3.995±2.72

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000228 IBA nuclear chromosome
GO:0000287 IDA magnesium ion binding
GO:0000400 IDA four-way junction DNA binding
GO:0000403 IBA Y-form DNA binding
GO:0000404 IBA heteroduplex DNA loop binding
GO:0000406 IBA double-strand/single-strand DNA junction binding
GO:0000710 IBA meiotic mismatch repair
GO:0001701 IEA in utero embryonic development
GO:0002204 IEA somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 IDA DNA binding
GO:0003684 IEA damaged DNA binding
GO:0003690 IDA double-stranded DNA binding
GO:0003697 IDA single-stranded DNA binding
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005634 IEA nucleus
GO:0006119 IEA oxidative phosphorylation
GO:0006200 IBA ATP catabolic process
GO:0006281 IDA DNA repair
GO:0006298 IDA:IEA mismatch repair
GO:0006301 IDA postreplication repair
GO:0006302 IBA double-strand break repair
GO:0006311 IBA meiotic gene conversion
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 IEA cell cycle arrest
GO:0007281 IEA germ cell development
GO:0008022 IPI protein C-terminus binding
GO:0008094 IBA DNA-dependent ATPase activity
GO:0008340 IEA determination of adult lifespan
GO:0008584 ISS male gonad development
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165 ISS response to X-ray
GO:0010224 ISS response to UV-B
GO:0016020 IDA membrane
GO:0016446 IBA somatic hypermutation of immunoglobulin genes
GO:0016447 ISS somatic recombination of immunoglobulin gene segments
GO:0016887 IDA ATPase activity
GO:0019237 IEA centromeric DNA binding
GO:0019724 ISS B cell mediated immunity
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030183 ISS B cell differentiation
GO:0030983 IDA:IEA mismatched DNA binding
GO:0031573 IBA intra-S DNA damage checkpoint
GO:0032137 IMP guanine/thymine mispair binding
GO:0032139 IDA dinucleotide insertion or deletion binding
GO:0032142 IDA single guanine insertion binding
GO:0032143 IDA single thymine insertion binding
GO:0032181 IDA dinucleotide repeat insertion binding
GO:0032301 IDA:IEA MutSalpha complex
GO:0032302 IDA:IEA MutSbeta complex
GO:0032357 IDA oxidized purine DNA binding
GO:0032405 IDA MutLalpha complex binding
GO:0042771 IBA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 IDA protein homodimerization activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0043531 IDA ADP binding
GO:0043570 IMP maintenance of DNA repeat elements
GO:0045128 IBA negative regulation of reciprocal meiotic recombination
GO:0045190 ISS isotype switching
GO:0045910 ISS negative regulation of DNA recombination
GO:0051096 IDA positive regulation of helicase activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000024967 Msh2-001 protein_coding Mus_musculus 0 3199
ENSMUST00000173097 Msh2-002 retained_intron Mus_musculus 0 1960
ENSMUST00000174703 Msh2-006 nonsense_mediated_decay Mus_musculus 0 370
ENSMUST00000172855 Msh2-005 protein_coding Mus_musculus 0 337
ENSMUST00000172596 Msh2-004 retained_intron Mus_musculus 0 331

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