ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: SRY (sex determining region Y)-box 17
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000297316 SOX17-001 ENSG00000164736 9606 + 8:54457935-54460888 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000297316
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000297316 24.071±2.63 26.098±10.56 19.935±0.00 40.444±0.00 22.121±13.72

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001525 ISS angiogenesis
GO:0001570 ISS vasculogenesis
GO:0001706 IDA endoderm formation
GO:0001828 IEA inner cell mass cellular morphogenesis
GO:0001947 ISS heart looping
GO:0003142 ISS cardiogenic plate morphogenesis
GO:0003143 ISS embryonic heart tube morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003308 IEA negative regulation of Wnt signaling pathway involved in heart development
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003705 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 IEA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0006355 ISS regulation of transcription, DNA-templated
GO:0007283 IEA spermatogenesis
GO:0007369 IEA gastrulation
GO:0007492 IEA endoderm development
GO:0007493 IEA endodermal cell fate determination
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0010628 IEA positive regulation of gene expression
GO:0021903 IEA rostrocaudal neural tube patterning
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0030308 IMP negative regulation of cell growth
GO:0031648 IMP protein destabilization
GO:0035050 ISS embryonic heart tube development
GO:0042074 IEA cell migration involved in gastrulation
GO:0042661 IEA regulation of mesodermal cell fate specification
GO:0042662 IEA negative regulation of mesodermal cell fate specification
GO:0042789 IDA mRNA transcription from RNA polymerase II promoter
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 ISS transcription regulatory region DNA binding
GO:0044798 IEA nuclear transcription factor complex
GO:0045595 IEA regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045995 ISS regulation of embryonic development
GO:0046982 IEA protein heterodimerization activity
GO:0048568 IEA embryonic organ development
GO:0048617 ISS embryonic foregut morphogenesis
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048863 IEA stem cell differentiation
GO:0048866 IEA stem cell fate specification
GO:0050821 IMP protein stabilization
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060214 ISS endocardium formation
GO:0060807 ISS regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
GO:0060913 IMP cardiac cell fate determination
GO:0060914 TAS heart formation
GO:0060956 ISS endocardial cell differentiation
GO:0061009 IEA common bile duct development
GO:0061010 IEA gall bladder development
GO:0061031 ISS endodermal digestive tract morphogenesis
GO:0072001 IMP renal system development
GO:0072091 IEA regulation of stem cell proliferation
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:2000035 IEA regulation of stem cell division
GO:2000043 IEA regulation of cardiac cell fate specification

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027035 Sox17-001 protein_coding Mus_musculus 0 1238
ENSMUST00000116652 Sox17-002 protein_coding Mus_musculus 0 1155
ENSMUST00000192650 Sox17-004 protein_coding Mus_musculus 0 885
ENSMUST00000195555 Sox17-005 protein_coding Mus_musculus 0 878
ENSMUST00000191939 Sox17-006 protein_coding Mus_musculus 0 617
ENSMUST00000192913 Sox17-003 protein_coding Mus_musculus 0 612
ENSMUST00000192505 Sox17-008 retained_intron Mus_musculus 0 361
ENSMUST00000191647 Sox17-007 protein_coding Mus_musculus 0 276

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