ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: ABL proto-oncogene 1, non-receptor tyrosine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000318560 ABL1-001 ENSG00000097007 9606 + 9:130835066-130887675 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000318560
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000318560 5.774±0.00 12.307±9.03 9.111±0.00 11.940±6.05

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0003677 NAS DNA binding
GO:0003785 TAS actin monomer binding
GO:0004515 TAS nicotinate-nucleotide adenylyltransferase activity
GO:0004672 IDA:IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 IDA:IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 TAS cytoplasm
GO:0005739 NAS mitochondrion
GO:0005829 IDA cytosol
GO:0006298 TAS mismatch repair
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006464 NAS cellular protein modification process
GO:0006468 IEA protein phosphorylation
GO:0006914 IEA autophagy
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0006979 IGI response to oxidative stress
GO:0007050 TAS cell cycle arrest
GO:0007067 TAS mitotic nuclear division
GO:0007155 IEA cell adhesion
GO:0007204 IMP positive regulation of cytosolic calcium ion concentration
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008022 IPI protein C-terminus binding
GO:0008630 TAS intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010506 TAS regulation of autophagy
GO:0015629 TAS actin cytoskeleton
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017124 IPI SH3 domain binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019905 IPI syntaxin binding
GO:0030036 ISS actin cytoskeleton organization
GO:0030100 TAS regulation of endocytosis
GO:0030145 IDA manganese ion binding
GO:0030155 TAS regulation of cell adhesion
GO:0034599 TAS cellular response to oxidative stress
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042692 TAS muscle cell differentiation
GO:0042770 IDA signal transduction in response to DNA damage
GO:0043065 IDA positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051019 IPI mitogen-activated protein kinase binding
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051353 IDA positive regulation of oxidoreductase activity
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0051882 TAS mitochondrial depolarization
GO:0070064 IDA proline-rich region binding
GO:0071901 IDA negative regulation of protein serine/threonine kinase activity
GO:1900275 IMP negative regulation of phospholipase C activity
GO:1903351 TAS cellular response to dopamine
GO:2000145 TAS regulation of cell motility
GO:2000249 TAS regulation of actin cytoskeleton reorganization
GO:2001020 IDA regulation of response to DNA damage stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000028190 Abl1-008 protein_coding Mus_musculus 0 3365
ENSMUST00000075759 Abl1-001 protein_coding Mus_musculus 0 3258
ENSMUST00000142554 Abl1-007 nonsense_mediated_decay Mus_musculus 0 2230
ENSDART00000149910 abl1-001 protein_coding Danio_rerio 0 1360
ENSDART00000005516 abl1-201 protein_coding Danio_rerio 0 1328
ENSDART00000148626 abl1-002 protein_coding Danio_rerio 0 1328
ENSMUST00000127714 Abl1-010 retained_intron Mus_musculus 0 675
ENSMUST00000135233 Abl1-005 nonsense_mediated_decay Mus_musculus 0 401
ENSMUST00000124089 Abl1-009 protein_coding Mus_musculus 0 399
ENSMUST00000124726 Abl1-011 retained_intron Mus_musculus 0 255

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