ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: protein kinase C, zeta
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378567 PRKCZ-001 ENSG00000067606 9606 + 1:2050470-2185395 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000378567
Transcript ID HAoEC HUVEC
ENST00000378567 4.325±0.85 3.656±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000226 IEA microtubule cytoskeleton organization
GO:0001954 IEA positive regulation of cell-matrix adhesion
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004697 IEA protein kinase C activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005635 IEA nuclear envelope
GO:0005737 TAS cytoplasm
GO:0005768 IEA endosome
GO:0005815 IEA microtubule organizing center
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005923 IEA tight junction
GO:0005938 IEA cell cortex
GO:0006468 IDA:IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 TAS signal transduction
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0007616 IEA long-term memory
GO:0008270 IEA zinc ion binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008286 IEA insulin receptor signaling pathway
GO:0015459 IEA potassium channel regulator activity
GO:0016020 TAS membrane
GO:0016324 IEA apical plasma membrane
GO:0016363 IEA nuclear matrix
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0019904 IEA protein domain specific binding
GO:0030010 ISS establishment of cell polarity
GO:0030054 TAS cell junction
GO:0030168 TAS platelet activation
GO:0031252 IEA cell leading edge
GO:0031333 IMP negative regulation of protein complex assembly
GO:0031532 IEA actin cytoskeleton reorganization
GO:0031584 IEA activation of phospholipase D activity
GO:0031941 IEA filamentous actin
GO:0032148 IEA activation of protein kinase B activity
GO:0032753 ISS positive regulation of interleukin-4 production
GO:0032869 IEA cellular response to insulin stimulus
GO:0034613 IEA cellular protein localization
GO:0035556 IEA intracellular signal transduction
GO:0035748 IEA myelin sheath abaxonal region
GO:0043066 IEA negative regulation of apoptotic process
GO:0043203 IEA axon hillock
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043234 IEA protein complex
GO:0043274 IEA phospholipase binding
GO:0043560 IC insulin receptor substrate binding
GO:0045121 IEA membrane raft
GO:0045179 IEA apical cortex
GO:0045630 ISS positive regulation of T-helper 2 cell differentiation
GO:0046326 IEA positive regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0046628 ISS positive regulation of insulin receptor signaling pathway
GO:0047496 IEA vesicle transport along microtubule
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050732 IMP negative regulation of peptidyl-tyrosine phosphorylation
GO:0050806 IEA positive regulation of synaptic transmission
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051222 IEA positive regulation of protein transport
GO:0051291 IEA protein heterooligomerization
GO:0051346 IEA negative regulation of hydrolase activity
GO:0051899 IEA membrane depolarization
GO:0060081 IEA membrane hyperpolarization
GO:0060291 ISS long-term synaptic potentiation
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070528 IEA protein kinase C signaling
GO:0071889 IEA 14-3-3 protein binding
GO:0072659 IEA protein localization to plasma membrane
GO:1990138 IEA neuron projection extension
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000553 ISS positive regulation of T-helper 2 cell cytokine production
GO:2000664 ISS positive regulation of interleukin-5 secretion
GO:2000667 ISS positive regulation of interleukin-13 secretion
GO:2001181 ISS positive regulation of interleukin-10 secretion

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000030922 Prkcz-001 protein_coding Mus_musculus 0 2375
ENSMUST00000103178 Prkcz-002 protein_coding Mus_musculus 0 1938
ENSMUST00000123652 Prkcz-004 protein_coding Mus_musculus 0 462
ENSMUST00000131975 Prkcz-006 protein_coding Mus_musculus 0 462
ENSMUST00000139647 Prkcz-005 processed_transcript Mus_musculus 0 327
ENSMUST00000125320 Prkcz-008 processed_transcript Mus_musculus 0 313
ENSMUST00000145373 Prkcz-007 processed_transcript Mus_musculus 0 196

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