ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: NLR family, pyrin domain containing 12
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000391775 NLRP12-003 ENSG00000142405 9606 - 19:53793742-53824317 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000391775
Transcript ID HAoEC HUVEC
ENST00000391775 0.240±0.22 0.036±0.01

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0006919 NAS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 NAS signal transduction
GO:0008588 IDA release of cytoplasmic sequestered NF-kappaB
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009968 IDA negative regulation of signal transduction
GO:0031953 IDA negative regulation of protein autophosphorylation
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0043122 IDA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 IDA regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 IDA positive regulation of MHC class I biosynthetic process
GO:0045381 NAS regulation of interleukin-18 biosynthetic process
GO:0045409 IDA negative regulation of interleukin-6 biosynthetic process
GO:0045751 IDA negative regulation of Toll signaling pathway
GO:0050710 IDA negative regulation of cytokine secretion
GO:0050711 IDA negative regulation of interleukin-1 secretion
GO:0050718 NAS positive regulation of interleukin-1 beta secretion
GO:0050728 IMP negative regulation of inflammatory response
GO:0050729 NAS positive regulation of inflammatory response

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000181320 Nlrp12-202 protein_coding Mus_musculus 0 1476
ENSMUST00000108653 Nlrp12-201 protein_coding Mus_musculus 0 1476

Loading