ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: Rho-associated, coiled-coil containing protein kinase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000399799 ROCK1-001 ENSG00000067900 9606 - 18:20946906-21111851 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000399799
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000399799 0.239±0.09 2.047±1.37 0.830±0.00 5.027±0.00 3.586±3.18

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0003383 IEA apical constriction
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 ISS cytoskeleton
GO:0005886 ISS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0006939 TAS smooth muscle contraction
GO:0007159 IDA leukocyte cell-cell adhesion
GO:0007165 TAS:IEA signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0007411 TAS axon guidance
GO:0016525 IMP negative regulation of angiogenesis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017048 IEA Rho GTPase binding
GO:0022614 IDA membrane to membrane docking
GO:0030027 ISS lamellipodium
GO:0030036 IEA actin cytoskeleton organization
GO:0030155 TAS regulation of cell adhesion
GO:0032060 IEA bleb assembly
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0032970 IEA regulation of actin filament-based process
GO:0035556 IEA intracellular signal transduction
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045616 IMP regulation of keratinocyte differentiation
GO:0046872 IEA metal ion binding
GO:0050900 IDA leukocyte migration
GO:0050901 IDA leukocyte tethering or rolling
GO:0051451 ISS myoblast migration
GO:0051492 TAS regulation of stress fiber assembly
GO:0051893 TAS regulation of focal adhesion assembly
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:2000114 TAS regulation of establishment of cell polarity
GO:2000145 TAS regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000067947 Rock1-201 protein_coding Mus_musculus 0 6431
ENSMUST00000020904 Rock2-201 protein_coding Mus_musculus 0 734

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