ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: tuberous sclerosis 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000401874 TSC2-003 ENSG00000103197 9606 + 16:2047989-2088702 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000401874
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000401874 20.176±9.42 6.629±0.00 15.337±10.26

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0005096 IDA:IEA GTPase activator activity
GO:0005488 IEA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 IDA cytosol
GO:0006469 ISS negative regulation of protein kinase activity
GO:0006606 ISS protein import into nucleus
GO:0006897 TAS endocytosis
GO:0007050 TAS cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007507 ISS heart development
GO:0008104 ISS protein localization
GO:0008285 ISS negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0014067 ISS negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 IDA membrane
GO:0016192 TAS vesicle-mediated transport
GO:0019902 IDA phosphatase binding
GO:0030100 ISS regulation of endocytosis
GO:0030178 IBA negative regulation of Wnt signaling pathway
GO:0032007 IBA negative regulation of TOR signaling
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0033596 IDA TSC1-TSC2 complex
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042803 IPI protein homodimerization activity
GO:0043491 ISS protein kinase B signaling
GO:0043547 IEA positive regulation of GTPase activity
GO:0045087 TAS innate immune response
GO:0046626 ISS regulation of insulin receptor signaling pathway
GO:0046627 IBA negative regulation of insulin receptor signaling pathway
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050918 ISS positive chemotaxis
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051726 IBA regulation of cell cycle
GO:0051898 ISS negative regulation of protein kinase B signaling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000097373 Tsc2-201 protein_coding Mus_musculus 0 5245

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