ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: insulin-like growth factor 1 (somatomedin C)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000424202 IGF1-004 ENSG00000017427 9606 - 12:102402459-102478651 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HUVECENST00000424202
Transcript ID HUVEC
ENST00000424202 0.241±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001501 TAS skeletal system development
GO:0001775 IDA cell activation
GO:0002576 TAS platelet degranulation
GO:0005158 IPI insulin receptor binding
GO:0005159 IPI insulin-like growth factor receptor binding
GO:0005178 IDA integrin binding
GO:0005179 IDA:IEA hormone activity
GO:0005515 IPI protein binding
GO:0005576 NAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0006260 TAS DNA replication
GO:0006928 TAS cellular component movement
GO:0007165 TAS signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007517 TAS muscle organ development
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0009441 TAS glycolate metabolic process
GO:0010613 IDA positive regulation of cardiac muscle hypertrophy
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834 IDA skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896 IMP muscle hypertrophy
GO:0014904 IDA myotube cell development
GO:0014911 IDA positive regulation of smooth muscle cell migration
GO:0016942 IC insulin-like growth factor binding protein complex
GO:0030166 IDA proteoglycan biosynthetic process
GO:0030168 TAS platelet activation
GO:0031093 TAS platelet alpha granule lumen
GO:0033160 IDA positive regulation of protein import into nucleus, translocation
GO:0034392 IDA negative regulation of smooth muscle cell apoptotic process
GO:0035630 IDA bone mineralization involved in bone maturation
GO:0040014 IEP regulation of multicellular organism growth
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0042523 IDA positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043388 IDA positive regulation of DNA binding
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043568 IDA positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 TAS cellular protein metabolic process
GO:0045445 IDA myoblast differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045725 IDA positive regulation of glycogen biosynthetic process
GO:0045740 ISS positive regulation of DNA replication
GO:0045821 IDA positive regulation of glycolytic process
GO:0045840 IDA positive regulation of mitosis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046326 IDA positive regulation of glucose import
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0048015 IDA phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051450 IDA myoblast proliferation
GO:0070886 IDA positive regulation of calcineurin-NFAT signaling cascade
GO:0090201 ISS negative regulation of release of cytochrome c from mitochondria
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000121161 Igf1-006 protein_coding Mus_musculus 0 688
ENSMUST00000062862 Igf1-002 protein_coding Mus_musculus 0 582
ENSMUST00000121952 Igf1-007 protein_coding Mus_musculus 0 575
ENSMUST00000122386 Igf1-005 protein_coding Mus_musculus 0 516
ENSMUST00000095360 Igf1-001 protein_coding Mus_musculus 0 516
ENSMUST00000126490 Igf1-008 protein_coding Mus_musculus 0 470
ENSMUST00000122100 Igf1-004 protein_coding Mus_musculus 0 436
ENSMUST00000105300 Igf1-003 protein_coding Mus_musculus 0 411
ENSDART00000004717 igf1-001 protein_coding Danio_rerio 2e-23 113

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