ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: interleukin-1 receptor-associated kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000448290 IRAK4-001 ENSG00000198001 9606 + 12:43758955-43788096 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000448290
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000448290 1.480±0.46 6.640±0.00 2.237±1.06

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001816 IEA cytokine production
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0004672 EXP:IEA protein kinase activity
GO:0004674 TAS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005149 IEA interleukin-1 receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007254 IEA JNK cascade
GO:0010008 TAS endosome membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response
GO:0048661 IEA positive regulation of smooth muscle cell proliferation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074936 Irak4-001 protein_coding Mus_musculus 0 1003
ENSMUST00000109248 Irak4-002 protein_coding Mus_musculus 0 968
ENSMUST00000183332 Rbm4b-007 retained_intron Mus_musculus 0.00005 55

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