ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: glutamate-cysteine ligase, modifier subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000023909 GCLM 9606 - 1:93885205-93909456 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000370238 GCLM-001 93885205-93909410 protein_coding
  ENST00000462183 GCLM-003 93904266-93908924 processed_transcript
  ENST00000467772 GCLM-002 93894644-93908790 processed_transcript
  ENST00000615724 GCLM-201 93887034-93909456 protein_coding
  ENST00000619076 GCLM-202 93887034-93909456 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000370238ENST00000467772ENST00000615724ENST00000619076
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000370238 3.724±0.00 5.843±5.64 6.216±0.00 3.631±2.73
ENST00000467772 N/A 16.045±3.63 14.277±0.00 18.300±4.15
ENST00000615724 1.539±0.00 3.257±0.87 N/A 3.873±2.04
ENST00000619076 1.738±0.09 3.618±1.80 4.784±0.00 3.826±2.19

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0009DH CIL_0009DH_0001 VISTA
CIL_0009DJ CIL_0009DJ_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0004357 IMP glutamate-cysteine ligase activity
GO:0005829 NAS cytosol
GO:0006534 IEA cysteine metabolic process
GO:0006536 IDA glutamate metabolic process
GO:0006749 IEA glutathione metabolic process
GO:0006750 IEA glutathione biosynthetic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006979 IDA response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0017109 IEA glutamate-cysteine ligase complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035226 IPI glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IEA positive regulation of glutamate-cysteine ligase activity
GO:0042493 IDA response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0046982 IEA protein heterodimerization activity
GO:0050880 IMP regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IEA regulation of mitochondrial depolarization
GO:1901687 TAS glutathione derivative biosynthetic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018953 gclm protein_coding Danio_rerio
ENSMUSG00000028124 Gclm protein_coding Mus_musculus

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