ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028124 Gclm 10090 + 3:122245557-122270732 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029769 Gclm-001 122245557-122270732 protein_coding
  ENSMUST00000137540 Gclm-003 122245712-122256971 processed_transcript
  ENSMUST00000149983 Gclm-002 122255587-122266943 protein_coding
  ENSMUST00000176445 Gclm-005 122246081-122265225 protein_coding
  ENSMUST00000176761 Gclm-004 122261779-122266255 retained_intron
  ENSMUST00000178826 Gclm-201 122245668-122266435 protein_coding
  ENSMUST00000199699 Gclm-006 122245988-122262616 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000029769ENSMUST00000149983ENSMUST00000178826
Transcript ID C166 Tie2+ EC mES
ENSMUST00000029769 3.440±0.38 3.364±1.50 1.551±0.32
ENSMUST00000149983 20.107±4.51 5.573±2.29 13.626±7.13
ENSMUST00000178826 20.163±3.71 15.387±0.52 9.885±4.76

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0009DI CIL_0009DI_0002 VISTA
CIL_0009DJ CIL_0009DJ_0002 VISTA
CIL_0009DH CIL_0009DH_0002 VISTA
CIL_00005U CIL_00005U_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004357 ISS glutamate-cysteine ligase activity
GO:0006534 IMP cysteine metabolic process
GO:0006536 ISS glutamate metabolic process
GO:0006749 IMP glutathione metabolic process
GO:0006750 ISS glutathione biosynthetic process
GO:0006979 ISS response to oxidative stress
GO:0008637 IGI apoptotic mitochondrial changes
GO:0017109 IDA glutamate-cysteine ligase complex
GO:0035226 ISS glutamate-cysteine ligase catalytic subunit binding
GO:0035229 IDA positive regulation of glutamate-cysteine ligase activity
GO:0042493 ISS response to drug
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0046982 IPI protein heterodimerization activity
GO:0050880 ISS regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IGI regulation of mitochondrial depolarization
GO:2001237 IGI negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018953 gclm protein_coding Danio_rerio
ENSG00000023909 GCLM glutamate-cysteine ligase, modifier subunit protein_coding Homo_sapiens

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