ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000046889 PREX2 9606 + 8:67952118-68237030 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288368 PREX2-001 67952118-68237030 protein_coding
  ENST00000517617 PREX2-003 67952489-68111089 processed_transcript
  ENST00000520235 PREX2-004 68157407-68220350 processed_transcript
  ENST00000522247 PREX2-005 68157375-68192630 processed_transcript
  ENST00000529398 PREX2-002 67952368-68106007 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000288368ENST00000517617ENST00000529398
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000288368 1.306±0.47 3.708±7.11 11.169±0.00 1.255±0.00 7.405±5.00
ENST00000517617 N/A 0.293±0.00 N/A N/A N/A
ENST00000529398 N/A N/A N/A N/A 11.921±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005BU CIL_0005BU_0002 CGP
CIL_00087Z CIL_00087Z_0001 VISTA
CIL_0001SD CIL_0001SD_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0008344 IEA adult locomotory behavior
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0030675 IDA Rac GTPase activator activity
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0048813 IEA dendrite morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071692 prex2 protein_coding Danio_rerio
ENSMUSG00000048960 Prex2 protein_coding Mus_musculus

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