ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: actinin, alpha 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077522 ACTN2 9606 + 1:236686454-236764631 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366578 ACTN2-001 236686508-236764631 protein_coding
  ENST00000461367 ACTN2-002 236753899-236762566 processed_transcript
  ENST00000492101 ACTN2-005 236747700-236748140 processed_transcript
  ENST00000492634 ACTN2-004 236686527-236744769 processed_transcript
  ENST00000494762 ACTN2-003 236737019-236742921 processed_transcript
  ENST00000542672 ACTN2-201 236686454-236764620 protein_coding
  ENST00000546208 ACTN2-202 236686454-236764620 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000366578ENST00000461367ENST00000492101ENST00000492634ENST00000494762ENST00000542672ENST00000546208
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000366578 0.010±0.00 0.728±0.38 N/A 0.093±0.00 0.031±0.02
ENST00000461367 N/A 2.024±0.51 0.177±0.00 0.099±0.00 0.146±0.06
ENST00000492101 0.293±0.00 N/A N/A N/A N/A
ENST00000492634 N/A 0.895±0.45 N/A N/A 0.051±0.03
ENST00000494762 0.159±0.00 N/A N/A N/A 0.157±0.02
ENST00000542672 N/A 0.447±0.11 N/A N/A 0.022±0.01
ENST00000546208 N/A 0.531±0.41 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00097Y CIL_00097Y_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002576 TAS platelet degranulation
GO:0005178 TAS integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005829 TAS cytosol
GO:0005856 NAS cytoskeleton
GO:0005884 TAS actin filament
GO:0005925 IMP focal adhesion
GO:0006936 IEA muscle contraction
GO:0007155 TAS cell adhesion
GO:0007268 TAS synaptic transmission
GO:0007596 TAS blood coagulation
GO:0008092 IDA cytoskeletal protein binding
GO:0008307 TAS structural constituent of muscle
GO:0030017 IEA sarcomere
GO:0030018 IDA Z disc
GO:0030035 IDA microspike assembly
GO:0030049 TAS muscle filament sliding
GO:0030168 TAS platelet activation
GO:0030175 IDA filopodium
GO:0030274 IEA LIM domain binding
GO:0030374 IEA ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 IEA thyroid hormone receptor coactivator activity
GO:0030864 IEA cortical actin cytoskeleton
GO:0031093 TAS platelet alpha granule lumen
GO:0031143 TAS pseudopodium
GO:0031432 IPI titin binding
GO:0042391 IMP regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0042981 NAS regulation of apoptotic process
GO:0043197 TAS dendritic spine
GO:0043267 IMP negative regulation of potassium ion transport
GO:0043268 IDA positive regulation of potassium ion transport
GO:0044325 IPI ion channel binding
GO:0046983 IDA protein dimerization activity
GO:0048041 IMP focal adhesion assembly
GO:0051015 IEA actin filament binding
GO:0051289 IDA protein homotetramerization
GO:0051373 IDA FATZ binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070080 IPI titin Z domain binding
GO:1901017 IMP negative regulation of potassium ion transmembrane transporter activity
GO:1901018 IDA positive regulation of potassium ion transmembrane transporter activity
GO:2000009 IMP negative regulation of protein localization to cell surface
GO:2000273 IEA positive regulation of receptor activity
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071090 actn2b protein_coding Danio_rerio
ENSMUSG00000052374 Actn2 protein_coding Mus_musculus

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