ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000092871 RFFL 9606 - 17:35005990-35089319 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000315249 RFFL-001 35005990-35089319 protein_coding
  ENST00000394597 RFFL-004 35009118-35063852 protein_coding
  ENST00000413582 RFFL-003 35011909-35042297 protein_coding
  ENST00000414419 RFFL-009 35021506-35088835 protein_coding
  ENST00000415395 RFFL-002 35011679-35042351 protein_coding
  ENST00000447669 RFFL-005 35011614-35089315 protein_coding
  ENST00000580569 RFFL-012 35007246-35008232 processed_transcript
  ENST00000581039 RFFL-011 35012002-35021411 protein_coding
  ENST00000581265 RFFL-008 35021622-35089194 nonsense_mediated_decay
  ENST00000582308 RFFL-010 35016462-35026568 protein_coding
  ENST00000584541 RFFL-007 35012049-35089247 processed_transcript
  ENST00000584655 RFFL-006 35009112-35089295 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHHSECHMVEC-DHUVECENST00000315249ENST00000394597ENST00000584655
Transcript ID HAoEC HHSEC HMVEC-D HUVEC
ENST00000315249 1.673±0.54 N/A N/A 2.624±1.14
ENST00000394597 2.343±0.51 N/A N/A 4.121±0.64
ENST00000584655 3.179±0.83 1.846±0.00 4.738±0.00 3.655±0.42

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00055Q CIL_00055Q_0001 CGP
CIL_00055O CIL_00055O_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0002039 IPI p53 binding
GO:0002947 IDA tumor necrosis factor receptor superfamily complex
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006886 IEA intracellular protein transport
GO:0008270 IEA zinc ion binding
GO:0010008 IDA endosome membrane
GO:0010762 ISS regulation of fibroblast migration
GO:0010804 IMP negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 IDA membrane
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016874 IEA ligase activity
GO:0019901 IPI protein kinase binding
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032006 IC regulation of TOR signaling
GO:0042787 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0061630 IDA ubiquitin protein ligase activity
GO:0070936 IDA protein K48-linked ubiquitination
GO:1901797 IMP negative regulation of signal transduction by p53 class mediator
GO:1902042 IMP negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 IMP negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042833 rffl protein_coding Danio_rerio
ENSMUSG00000020696 Rffl protein_coding Mus_musculus

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