ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: serine/threonine kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101109 STK4 9606 + 20:44966474-45079959 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000372801 STK4-006 44966522-45075608 protein_coding
  ENST00000372806 STK4-003 44966474-45079959 protein_coding
  ENST00000474717 STK4-005 44970542-44995257 protein_coding
  ENST00000480745 STK4-001 44966539-44974404 processed_transcript
  ENST00000487587 STK4-002 44966553-44975684 nonsense_mediated_decay
  ENST00000488618 STK4-004 44966515-44972920 processed_transcript
  ENST00000499879 STK4-201 44966479-45079948 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000372806ENST00000487587ENST00000499879
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000372806 N/A 4.570±2.01 5.593±0.00 4.956±3.28
ENST00000487587 N/A N/A N/A 1.364±0.00
ENST00000499879 1.485±0.00 N/A N/A 1.196±0.58

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003UT CIL_0003UT_0001 CGP
CIL_0003US CIL_0003US_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0000902 IDA cell morphogenesis
GO:0001569 IEA patterning of blood vessels
GO:0001841 IEA neural tube formation
GO:0003157 IEA endocardium development
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 IDA apoptotic process
GO:0007165 TAS signal transduction
GO:0007417 IEA central nervous system development
GO:0008134 IPI transcription factor binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0030216 IEA keratinocyte differentiation
GO:0035329 TAS hippo signaling
GO:0035556 IDA intracellular signal transduction
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043065 IDA positive regulation of apoptotic process
GO:0043539 TAS protein serine/threonine kinase activator activity
GO:0046621 IEA negative regulation of organ growth
GO:0046777 IDA protein autophosphorylation
GO:0046983 IDA protein dimerization activity
GO:0060215 IEA primitive hemopoiesis
GO:0060706 IEA cell differentiation involved in embryonic placenta development
GO:0071902 TAS positive regulation of protein serine/threonine kinase activity
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0097284 IEA hepatocyte apoptotic process
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000018209 Stk4 protein_coding Mus_musculus

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