ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: prostaglandin I2 (prostacyclin) synthase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124212 PTGIS 9606 - 20:49503874-49568146 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000244043 PTGIS-001 49503874-49568146 protein_coding
  ENST00000478971 PTGIS-002 49507901-49568116 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000244043ENST00000478971
Transcript ID BECs HAoEC HUVEC
ENST00000244043 0.178±0.04 0.797±0.31 2.559±1.99
ENST00000478971 N/A 0.871±0.22 1.739±0.82

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006IT CIL_0006IT_0002 CGP
CIL_0008I4 CIL_0008I4_0001 VISTA
CIL_0001RU CIL_0001RU_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 IDA prostaglandin biosynthetic process
GO:0004497 IEA monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005615 ISS extracellular space
GO:0005634 IDA nucleus
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005901 IDA caveola
GO:0006690 TAS icosanoid metabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0008116 IDA prostaglandin-I synthase activity
GO:0016021 IEA integral component of membrane
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019369 TAS arachidonic acid metabolic process
GO:0019371 TAS cyclooxygenase pathway
GO:0020037 IDA:IEA heme binding
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0035360 IDA positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0044281 TAS small molecule metabolic process
GO:0045019 IDA negative regulation of nitric oxide biosynthetic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0050728 IDA negative regulation of inflammatory response
GO:0055114 IEA oxidation-reduction process
GO:0071347 IEP cellular response to interleukin-1
GO:0071354 IEP cellular response to interleukin-6
GO:0071456 IDA cellular response to hypoxia
GO:0097190 IDA apoptotic signaling pathway
GO:1900119 IDA positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060094 ptgis protein_coding Danio_rerio
ENSMUSG00000017969 Ptgis protein_coding Mus_musculus

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